Proliferative vitreoretinopathy (PVR) is a complex disease process that is not completely understood. While certain features are shared among eyes with PVR, no 2 eyes are exactly the same. The surgical management of PVR is also complex and involves numerous decisions and manipulations often based on subjective assessments. This makes it difficult to evaluate treatment of PVR.
The Silicone Study was designed to evaluate one of the many decisions involved in the management of PVR, whether to use silicone oil or 1 of 2 types of gas for tamponade. In June 1992, the first 2 reports were published and indicated that at 6 or 24 months after surgery, a greater percentage of eyes randomized to silicone oil had an attached macula and a visual acuity better than 5/200 compared with eyes randomized to sulfur hexafluoride,1 but there was no difference compared with eyes randomized to perfluoropropane (C3F
Campochiaro PA. The Silicone StudyA Small Piece of the PVR Puzzle Is Put Into Place. Arch Ophthalmol. 1997;115(3):407-408. doi:10.1001/archopht.1997.01100150409016