We have recently observed a case of bilateral granulomatous anterior uveitis with elevation of intraocular pressure (IOP) in a patient being treated for open-angle glaucoma with metipranolol (Optipranolol, Bausch & Lomb, Tampa, Fla). When the uveitis cleared, the patient was treated with timolol maleate (Timoptic, Merck & Co Inc, West Point, Pa) in 1 eye and metipranolol in the other eye. The metipranolol-treated eye had a recurrence of uveitis and an increase in IOP while the timololtreated eye remained stable with excellent IOP control. To our knowledge, this is the first case in the United States in which a proven recurrence of uveitis was associated with metipranolol.
Report of a Case.
A 73-year-old white man was diagnosed as having open-angle glaucoma in August 1994 after identification of a disc hemorrhage and onset of a superior arcuate defect in the right eye. His visual acuity was 20/25 OU, IOP was 21
Watanabe TM, Hodes BL. Bilateral Anterior Uveitis Associated With a Brand of Metipranolol. Arch Ophthalmol. 1997;115(3):421-422. doi:10.1001/archopht.1997.01100150423020