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June 1997

Primary Choroidal Melanoma in a Patient With Previous Cutaneous Melanoma

Author Affiliations

From the Departments of Opthalmology (Drs Scull, Alcocer, Deschênes, and Burnier), Pathology (Dr Burnier), and Medicine (Dr Burnier), Royal Victoria Hospital, McGill University Faculty of Medicine, Montreal, Quebec.

Arch Ophthalmol. 1997;115(6):796-798. doi:10.1001/archopht.1997.01100150798019

A 67-year-old woman with a history of a skin melanoma that was excised 7 years previously had a 6-month history of decreased vision in her right eye. A choroidal melanoma was diagnosed clinically, and the eye was enucleated. The results of a histopathological examination revealed a primary uveal melanoma. Slides of the skin melanoma were obtained, and the initial diagnosis was confirmed. In an attempt to illustrate a biological difference between the 2 melanomas, immunohistochemical studies were performed on sections of the 2 specimens using S-100 protein, HMB-45, and S-100-β. Primary cutaneous and choroidal melanomas appearing in a patient with no predisposition are rare; this is believed to be only the fifth such case reported in the literature.