We describe a patient with an incidental finding of an expansile osteolytic lesion centered in the sphenoid involving 3 cranial bones—frontal, temporal, and sphenoid—and invading the brain parenchyma and orbit. Biopsy demonstrated an epidermoid. The lesion was excised through frontotemporal craniotomy. Despite the benign nature of the tumor, the epidermoid had a destructive pattern of growth. Complete resection was needed to adequately address the inflammatory mass effect of the large lesion.
Rumelt S, Harsh GR, Rubin PAD. Giant Epidermoid Involving 3 Cranial Bones. Arch Ophthalmol. 1997;115(7):922-924. doi:10.1001/archopht.1997.01100160092019