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July 1997

Subretinal Fluid Associated With Membranoproliferative Glomerulonephritis Type 2

Author Affiliations

Iowa City, Iowa
Nashville, Tenn

Arch Ophthalmol. 1997;115(7):927-928. doi:10.1001/archopht.1997.01100160097022

Membranoproliferative glomerulonephritis type 2 (MPGN2) is associated with electron-dense deposits in the basement membrane of the retinal pigment epithelium (RPE) that ophthalmoscopically resemble basal laminar drusen.1 Choroidal neovascularization2 and idiopathic central serous chorioretinopathy (ICSC)3 are recognized complications of this dense deposit retinopathy. We describe subretinal fluid accumulation in a patient with MPGN2 with initial angiographic findings mimicking choroidal neovascularization. Resolution of the fluid and angiographic findings occurred after several weeks without treatment.

Report of a Case.  A 38-year-old man was seen after experiencing blurred vision in the right eye for 2 days. Fifteen years before he had undergone laser photocoagulation in the left eye for choroidal neovascularization. He had medically controlled hypertension and had undergone kidney transplantation for renal failure secondary to MPGN2 at the age of 34 years. His medications included cyclosporine, prednisone, metoprolol, enalapril, diltiazem, terazosin, bumetanide, and a multivitamin. His visual acuity was 20/20

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