[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.161.168.87. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
November 1997

Serum Sulfotransferase Levels in Patients With Macular Corneal Dystrophy Type I

Author Affiliations

From the Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pa (Dr Hassell), and the Departments of Ophthalmology and Pathology, Duke University Medical Center, Durham, NC (Dr Klintworth).

Arch Ophthalmol. 1997;115(11):1419-1421. doi:10.1001/archopht.1997.01100160589011
Abstract

Objective:  To measure the levels of sulfotransferase activity for keratan sulfate and chondroitin sulfate in serum of patients with macular corneal dystrophy type I, an inherited disorder that is characterized by the absence of sulfate esters on keratan sulfate in the corneal stroma.

Methods:  The amount of sulfur-35 transferred from 3′-phosphoadenosine 5′-phosphosulfate to partially sulfated keratan sulfate and partially sulfated chondroitin sulfate by the sulfotransferase present in serum from patients with macular corneal dystrophy and agematched controls was determined under conditions where only the added enzyme was rate limiting.

Results:  Serum from patients with macular corneal dystrophy type I has the same level of sulfotransferase activity for keratan sulfate and chondroitin sulfate as found in age-matched controls.

Conclusions:  Patients with macular corneal dystrophy type I have sulfotransferase activity for sulfating at least 1 of the 2 sugars in keratan sulfate. It is proposed that the sulfotransferase for N-acetylglucosamine may be deficient.

×