In vivo scanning slit confocal microscopy was performed in a patient with Fusarium solani keratitis. Morphologically distinctive abundant filamentous structures were observed intrastromally. Confocal microscopy of the culture plate growing F solani from the patient's corneal scraping revealed filaments morphologically similar to the filaments observed in vivo. After 1 week of medical therapy, subsequent confocal microscopy showed an increased load of filaments, supporting the decision to perform a penetrating keratoplasty. Confocal microscopy confirmed that all of the fungus was eradicated. This aided in the decision to administer corticosteroids and quickly discontinue antifungal agents.
Florakis GJ, Moazami G, Schubert H, Koester CJ, Auran JD. Scanning Slit Confocal Microscopy of Fungal Keratitis. Arch Ophthalmol. 1997;115(11):1461-1463. doi:10.1001/archopht.1997.01100160631019