November 1997

Non-Hodgkin Lymphoma and Kaposi Sarcoma in an Eyelid of a Patient With Acquired Immunodeficiency SyndromeMultiple Viruses in Pathogenesis

Author Affiliations

From the Departments of Ophthalmology (Drs Tunc and Char), Pathology (Drs Simmons and Herndier), and Radiation Oncology (Dr Char), University of California, San Francisco, and the Francis I. Proctor Foundation, San Francisco (Dr Char).

Arch Ophthalmol. 1997;115(11):1464-1466. doi:10.1001/archopht.1997.01100160634020

A 36-year-old patient with the acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. The histopathologic examination revealed a high-grade diffuse large cell non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ hybridization revealed Epstein-Barr virus in the large cell lymphoma and Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. This collision tumor is an unusual presentation of 2 malignant neoplasms in a patient with acquired immunodeficiency syndrome, with in situ hybridization evidence of Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus in the lesion.