A 36-year-old patient with the acquired immunodeficiency syndrome sought care because of an upper eyelid lesion that dramatically increased in size. The histopathologic examination revealed a high-grade diffuse large cell non-Hodgkin lymphoma in continuity with a Kaposi sarcoma. In situ hybridization revealed Epstein-Barr virus in the large cell lymphoma and Kaposi sarcoma-associated herpesvirus in the Kaposi sarcoma lesion. This collision tumor is an unusual presentation of 2 malignant neoplasms in a patient with acquired immunodeficiency syndrome, with in situ hybridization evidence of Epstein-Barr virus and Kaposi sarcoma-associated herpesvirus in the lesion.
Tunc M, Simmons ML, Char DH, Herndier B. Non-Hodgkin Lymphoma and Kaposi Sarcoma in an Eyelid of a Patient With Acquired Immunodeficiency SyndromeMultiple Viruses in Pathogenesis. Arch Ophthalmol. 1997;115(11):1464-1466. doi:10.1001/archopht.1997.01100160634020