December 1997

A Case of Primary Choroidal Melanoma in a Patient With Previous Cutaneous Melanoma-Reply

Author Affiliations

Montreal, Quebec

Arch Ophthalmol. 1997;115(12):1606. doi:10.1001/archopht.1997.01100160776029

In reply  We thank Dr Abramson and Ms Servodidio for their interest in our article.1 We had several reasons for describing this patient with a history of cutaneous melanoma that was excised 7 years prior to the development of a choroidal melanoma. The main reason was to analyze the difficulties that arise in the differential diagnosis between 2 primary tumors vs metastatic disease. We discussed the fact that the ocular tumor was seen as a single choroidal nodule 7 years after the cutaneous melanoma had been removed. In addition to the absence of systemic disease, this strongly suggests that this patient had 2 primary tumors. We also discussed the value of immunohistochemical markers, particularly S100-β, as a possible tool to aid in the histopathological differential diagnosis between primary and metastatic choroidal melanomas.Abramson and coworkers2 described a 51 -year-old man who had dysplastic nevus syndrome or B-K mole

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