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February 1, 2017, Vol 135, No. 2, Pages 81-176

Ophthalmic Images

Castleman Disease and Retinal Vascular Tortuosity

Abstract Full Text
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JAMA Ophthalmol. 2017;135(2):e164660. doi:10.1001/jamaophthalmol.2016.4660

A man in his 30s with Castleman disease 15 years after a lung transplant has venous engorgement and tortuosity bilaterally on fundus examination and fluorescein angiography.

Selective Extraocular Muscle Atrophy Secondary to Chronic Oculomotor Denervation

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JAMA Ophthalmol. 2017;135(2):e164664. doi:10.1001/jamaophthalmol.2016.4664

A woman in her 60s who had undergone strabismus surgery 20 years prior has selective extraocular muscle atrophy on magnetic resonance imaging secondary to chronic oculomotor denervation.

Ultrasound Biomicroscopy of Anterior Chamber Angle Structures After Gonioscopy-Assisted Transluminal Trabeculotomy

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JAMA Ophthalmol. 2017;135(2):e164931. doi:10.1001/jamaophthalmol.2016.4931

A woman in her 40s underwent gonioscopy-assisted transluminal trabeculotomy to reduce intraocular pressure. Ultrasound biomicroscopy images show the altered anterior chamber angle anatomy.

Regression of Iris Metastasis After Systemic Treatment With Melanoma-Targeted Therapy

Abstract Full Text
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JAMA Ophthalmol. 2017;135(2):e165462. doi:10.1001/jamaophthalmol.2016.5462

A man in his 40s with sudden-onset blurred vision has cutaneous melanoma metastasis.

In This Issue of JAMA Ophthalmology

Highlights

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JAMA Ophthalmol. 2017;135(2):81. doi:10.1001/jamaophthalmol.2016.3717
Viewpoint

Listening to the Patients—The Laser-Assisted In Situ Keratomileusis Quality of Life Collaboration Project

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):83-84. doi:10.1001/jamaophthalmol.2016.4585

This Viewpoint discusses the Laser-Assisted In Situ Keratomileusis (LASIK) Quality of Life Collaboration Project, which developed a questionnaire to capture the patient’s experience following LASIK surgery with the ultimate goal of quantifying these patient-reported outcomes in the LASIK population.

Original Investigation

Intravitreal Aflibercept Injection in Eyes With Substantial Vision Loss After Laser Photocoagulation for Diabetic Macular EdemaSubanalysis of the VISTA and VIVID Randomized Clinical Trials

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):107-114. doi:10.1001/jamaophthalmol.2016.4912

This post hoc analysis of the VISTA and VIVID randomized clinical trials evaluates visual and anatomic outcomes in a subgroup of macular laser photocoagulation treatment control eyes with substantial vision loss receiving treatment with intravitreal aflibercept injection.

Longitudinal Examination of Frequency of and Risk Factors for Severe Dry Eye Symptoms in US Veterans

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JAMA Ophthalmol. 2017;135(2):116-123. doi:10.1001/jamaophthalmol.2016.4925

This longitudinal study of US veterans assesses symptom progression in dry eye syndrome and determines risk factors associated with severe symptoms at 1 year.

Association Between Endothelial Cell Density and Transplant Suitability of Corneal Tissue With Type 1 and Type 2 Diabetes

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):124-130. doi:10.1001/jamaophthalmol.2016.5095

This database study examines the association between endothelial cell density and suitability for transplantation in cornea donors with type 1 or 2 diabetes and determines the effect of diabetes on technician-induced endothelial damage during cornea donor tissue processing.

A Tiered Approach to Retinopathy of Prematurity Screening (TARP) Using a Weight Gain Predictive Model and a Telemedicine System

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):131-136. doi:10.1001/jamaophthalmol.2016.5203

This post hoc analysis of infants in the e-ROP and G-ROP studies describes a tiered approach to retinopathy of prematurity (ROP) screening for identifying children who develop severe ROP using telemedicine and a predictive model synergistically.

Clinical Characterization of CNGB1-Related Autosomal Recessive Retinitis Pigmentosa

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):137-144. doi:10.1001/jamaophthalmol.2016.5213

This case series describes clinical and genetic findings in patients with CNGB1-associated retinitis pigmentosa.

Cost and Expected Visual Effect of Interventions to Improve Follow-up After Cataract SurgeryProspective Review of Early Cataract Outcomes and Grading (PRECOG) Study

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):85-94. doi:10.1001/jamaophthalmol.2016.4735

This multicenter cohort study from 8 low- and middle-income countries in Africa, Asia, and Latin America examines whether strategies to promote follow-up after cataract surgery have economic value.

Outcomes of the Veterans Affairs Low Vision Intervention Trial II (LOVIT II)A Randomized Clinical Trial

Abstract Full Text
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JAMA Ophthalmol. 2017;135(2):96-104. doi:10.1001/jamaophthalmol.2016.4742

This randomized clinical trial evaluates the effectiveness of rehabilitation services provided with low-vision devices compared with basic services accompanying the devices used in veterans with low vision due to macular diseases.

Brief Report

Evaluating Effects of Switching Anti–Vascular Endothelial Growth Factor Drugs for Age-Related Macular Degeneration and Diabetic Macular Edema

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):145-149. doi:10.1001/jamaophthalmol.2016.4820

This study assesses outcomes in patients who have a poor initial response but continue treatment without switching anti–vascular endothelial growth factor agents.

Association of Low Vitamin D Levels With Noninfectious Anterior Uveitis

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):150-153. doi:10.1001/jamaophthalmol.2016.4888

This case-control study evaluates whether there is an association between vitamin D levels and noninfectious anterior uveitis.

Invited Commentary

Demonstrating the Effectiveness of Low-Vision Rehabilitation With Outcomes of the Veterans Affairs Low Vision Intervention Trial II (LOVIT II)

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):105-106. doi:10.1001/jamaophthalmol.2016.4778

Further Scrutiny of Vision Outcomes When Aflibercept Is Used as Rescue Treatment for Eyes With Diabetic Macular Edema Treated With Laser

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):114-115. doi:10.1001/jamaophthalmol.2016.4936

Combating Cataract Blindness

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):94-95. doi:10.1001/jamaophthalmol.2016.4779
JAMA Ophthalmology Clinical Challenge

Dark Retinal Lesion in a Young Asymptomatic Man

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):155-156. doi:10.1001/jamaophthalmol.2016.2839

A visually asymptomatic Hispanic man in his early 20s had a nodular, darkly pigmented lesion with well-defined margins located inferonasal to the foveola. What would you do next?

Unilateral Optic Nerve Edema With Preserved Visual Function

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):157-158. doi:10.1001/jamaophthalmol.2016.3787

A man in his 50s reported a 4-week history of intermittent blurry vision in the right eye. Best-corrected visual acuity was 20/20 OU, and on ophthalmoscopy, there were few vitreous cells with no detectable haze and optic nerve head edema grade IV on the Frisén scale, with peripapillary flame hemorrhages in the right eye. What would you do next?

Bilateral Optic Nerve Head Changes in an Asymptomatic Preadolescent Girl

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):159-160. doi:10.1001/jamaophthalmol.2016.2855

A preadolescent girl was seen for evaluation and treatment of possible papilledema. Her ocular, medical, and family history were unremarkable and she had recently used a short-term course of oral antibiotics for a tooth infection. What would you do next?

The Masquerade Syndrome

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):161-162. doi:10.1001/jamaophthalmol.2016.2890

A man in his 50s with a history of basal cell carcinoma that was resected from the right medial canthus was referred with right-sided ptosis, conjunctival hyperemia, and recurrent central corneal erosions. On examination, he was found to have complete ptosis of the right eyelid, asymmetric erythema of the eyelid margin, and meibomian gland dysfunction, as well as papillary conjunctivitis with thickening of his medial right lower eyelid. What would you do next?

Research Letter

Rates of Routine Cataract Surgery Among Medicare Beneficiaries

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):163-165. doi:10.1001/jamaophthalmol.2016.5174

This study explores the rates of cataract surgery among US Medicare beneficiaries to assess geographic variation at the county level.

Observation

Electrophysiologic Effects of Very High-Dose Sildenafil

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):165-167. doi:10.1001/jamaophthalmol.2016.4017

A man in his 60s experienced blurring in both eyes after taking a very high dose of sildenafil.

An Unusual Retinal Phenotype Associated With a Mutation in Sterol Carrier Protein SCP2

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):167-169. doi:10.1001/jamaophthalmol.2016.4985

A man in his 50s with a 4-year history of ataxia and SCP2 deficiency has unusual ophthalmic manifestations.

Acute Posterior Multifocal Placoid Pigment Epitheliopathy Associated With Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):169-171. doi:10.1001/jamaophthalmol.2016.5230

A 55-year-old man presented with bilateral “splotchy vision” for 10 days and was diagnosed with drug reaction with eosinophilia and systemic symptoms syndrome.

Comment & Response

Nontechnical Factors in the Simulation of Ophthalmological Procedures

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):172. doi:10.1001/jamaophthalmol.2016.4805

Nontechnical Factors in the Simulation of Ophthalmological Procedures—Reply

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):172-173. doi:10.1001/jamaophthalmol.2016.4807

Comparison of Recent Studies of Postoperative Endophthalmitis From the Same National Database

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):173. doi:10.1001/jamaophthalmol.2016.5093

Comparison of Recent Studies of Postoperative Endophthalmitis From the Same National Database

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):173-174. doi:10.1001/jamaophthalmol.2016.5105

Comparison of Recent Studies of Postoperative Endophthalmitis From the Same National Database—Reply

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):174-175. doi:10.1001/jamaophthalmol.2016.5107

Prognostic Implications of the Largest Basal Tumor Diameter vs the TNM Staging System in Association With the Gene Expression Profile for Uveal Melanoma

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):175. doi:10.1001/jamaophthalmol.2016.5102

Prognostic Implications of the Largest Basal Tumor Diameter vs the TNM Staging System in Association With the Gene Expression Profile for Uveal Melanoma—Reply

Abstract Full Text
JAMA Ophthalmol. 2017;135(2):175-176. doi:10.1001/jamaophthalmol.2016.5109
JAMA Ophthalmology Masthead

JAMA Ophthalmology

Abstract Full Text
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JAMA Ophthalmol. 2017;135(2):82. doi:10.1001/jamaophthalmol.2016.3718
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