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Clinicopathologic Reports, Case Reports, and Small Case Series
August 2003

Congenital Toxoplasmosis With Unusual Retinal Findings

Arch Ophthalmol. 2003;121(8):1200-1201. doi:10.1001/archopht.121.8.1200

Toxoplasmosis is the most common cause of infectious retinitis in otherwise healthy individuals.1 In the United States, 70% to 80% of women at childbearing age are at risk of developing a primary infection.2 Infants with congenital toxoplasmosis may or may not have clinical evidence of disease. Active disease is characterized by encephalitis, lymphadenopathy, hepatosplenomegaly, pneumonitis, jaundice, rash, thrombocytopenia with petechiae, and a range of neurological manifestations that include microcephaly and seizures.3 A classic triad of convulsions, intracranial calcifications, and chorioretinitis has been associated with congenital infection with Toxoplasma. The presence of this triad of findings, however, is not necessary to establish the diagnosis. Congenital toxoplasmosis can be made on the basis of serologic evidence (Ig G and Ig M titers) and central nervous system manifestations. Chorioretinal scarring is the most common ocular manifestation of congenital toxoplasmosis, but occasionally acute chorioretinitis is seen in the early neonatal period.

We report an unusual case of congenital toxoplasmosis with panuveitis and an associated retinal fold in one eye and a total retinal detachment in the fellow eye.

Report of a Case

A 1-month-old Asian girl with a history of irritability and fever was referred for evaluation of asymmetric red reflexes. The infant's mother had a history of fever and lymphadenopathy involving the cervical lymph nodes at the fourth gestational month, but she had not been medically evaluated. She also had a history of eating undercooked meat early in the pregnancy. There was no family history of inherited retinal diseases.

On ophthalmic examination, the infant had light response in the right eye but no light response in the left eye. The pupils were 3 mm OD with a brisk response to light and 1 mm OS with no light response. There was a left afferent pupillary defect. Anterior segment examination of the right eye revealed moderate cells with no other abnormalities. Anterior segment examination of the left eye revealed a clear cornea, a flat anterior chamber with 360° of iris neovascularization, and seclusio pupilla. Intraocular pressure was 14 mmHg OU. Findings from the dilated fundus examination of the right eye revealed a retinal fold extending from the optic nerve through the macula to the vitreous base at the 9-o'clock position associated with mild vitritis(Figure 1). There was no view of the retina of the left eye.

Figure 1.
Fundus of the right eye showing a retinal fold extending from the optic nerve through the macula to the vitreous base at the 9-o'clock position.

Fundus of the right eye showing a retinal fold extending from the optic nerve through the macula to the vitreous base at the 9-o'clock position.

Computed tomographic (CT) scan of the orbit and B-scan ultrasonography revealed an inoperable funnel retinal detachment in the left eye. Computed tomographic scan of the brain demonstrated multiple areas of subcortical calcification.(Figure 2) The fundus examination findings from the parents were normal. Blood cultures of the infant were negative for organisms. Initial serologic testing results were positive for Toxoplasma Ig G and negative for Toxoplasma Ig M. A subsequent Ig M titer for Toxoplasma was positive. The infant's mother had an Ig G titer positive for Toxoplasma and an Ig M titer negative for that organism. Findings from the cerebrospinal fluid culture were negative for organisms, and the values for its components were normal apart from a high total protein level (127mg/d L). A vitreous biopsy and aspiration of the left eye were performed. The culture was negative for organisms and the findings from polymerase chain reaction analysis of the aspirate were positive for Toxoplasma gondii and negative for Toxocara canis, herpes simplex virus, herpes zoster virus, and Cytomegalovirus.

Figure 2.
Computed tomographic scan of the brain with contrast showing multiple areas of subcortical calcification.

Computed tomographic scan of the brain with contrast showing multiple areas of subcortical calcification.

A diagnosis of congenital toxoplasmosis was established, and the patient was treated with a 6-month course of sulfadiazine, pyrimethamine, and leucovorin calcium. Topical steroids were used to treat the iridocyclitis of the right eye. At 9 months of age, the infant had roving nystagmus and a sensory esotropia. Follow-up examination 9 months later demonstrated no active iridocyclitis, vitritis, or retinitis, but there was a stable retinal fold in the right eye.

Comment

Toxoplasmic chorioretinitis is the most common ocular manifestation of both congenital and acquired toxoplasmosis. Retinal detachment, mostly of a tractional origin, occurs in only 10% of cases of congenital toxoplasmosis.4

Among the entities that were considered in the differential diagnosis of this case were viral retinides, toxocariasis, familial exudative vitreoretinopathy, Norrie disease, and retinoblastoma. A normal family medical history, negative findings for organisms on serologic testing and culturing, and the clinical picture helped to exclude these other possibilities. Although clinical manifestations are usually sufficient to diagnose both congenital and acquired toxoplasmosis, occasionally it presents a diagnostic challenge. In this case, the presence of a macular retinal fold in the absence of the typical chorioretinal lesions and the Ig M titer that was initially negative for toxoplasmosis presented a diagnostic challenge. The use of all available investigations, including polymerase chain reaction analysis of the ocular fluid, and viewing this case in the context of other nonocular manifestations helped us reach the proper diagnosis. The prevalence of congenital toxoplasmosis is decreasing and clinicians may be less likely to think of it as a cause of disease, especially when it is atypical in appearance. We report this case of congenital toxoplasmosis because of its atypical ocular presentation.

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Article Information

This study was supported in part by an unrestricted research grant from Research to Prevent Blindness, Inc, New York, NY.

The authors have no relevant financial interest in this article.

Corresponding author: Evelyn A. Paysse, MD, Baylor College of Medicine, Texas Children's Hospital, 6621 Fannin St, CC 640.00, Houston, TX 77030 (e-mail: epaysse@bcm.tmc.edu).

References
1.
Holland  GNO'Connor  GRBelfore  RRemington  JS Toxoplasmosis. In:Pepose  JSHolland  GNWilhelmus  KReds.Ocular Infection and Immunity St Louis, Mo Mosby–Year Book, Inc1996;1183- 1223
2.
Kimball  ACKean  BHFuchs  F Congenital toxoplasmosis: a prospective study of 4, 048 obstetric patients. Am J Obstet Gynecol. 1971;111211- 218
PubMed
3.
Alford  CA  JrStagno  SReynolds  DW Congenital toxoplasmosis: clinical, laboratory, and considerations, with special reference to subclinical disease. Bull N Y Acad Med. 1974;50160- 181
4.
Mets  MBHolfels  EBoyer  KM  et al.  Eye manifestations of congenital toxoplasmosis. Am J Ophthalmol. 1996;122309- 324
PubMed
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