Descemet stripping automated endothelial keratoplasty (DSAEK) is a new treatment option for corneal endothelial dysfunction. Compared with penetrating keratoplasty, DSAEK is less invasive and leads to more rapid visual recovery.
The most common complications after DSAEK described in the literature are graft detachment and/or dislocation, rejection, epithelial ingrowth, and pupillary block, all of which can lead to graft failure.1- 3
Interface corneal deposits and/or debris have been described after laser in situ keratomileusis but have not been associated with DSAEK.4,5In this case series, we describe 2 patients after DSAEK with the appearance of characteristic wavelike deposit accumulation at the donor-recipient interface in the immediate postoperative period.
Patients were asked to sign an informed consent form prior to treatment. Institutional review board approval was obtained before medical record review. The operations were successful and without complications in both cases. The precut lamellar corneal DSAEK grafts were provided by eye banks. The DSAEK donor tissues were prepared using a Moria (Antony, France) automated microkeratome and a Moria artificial chamber. Optisol GS solution (Bausch & Lomb Surgical, Irvine, California) was used as storage medium. The folded donor tissues were grasped gently using angled nonappositional forceps (Charlie forcep; Moria) and inserted into the eye. Venting incisions were made to remove interface fluid.
A 73-year-old female patient with Fuchs endothelial dystrophy and pseudophakia had DSAEK for bullous keratopathy. Preoperatively, the best spectacle-corrected visual acuity (BSCVA) in this eye was 20/70. On postoperative day 1, characteristic interface wavelike deposit accumulation was visible on slitlamp examination despite corneal edema. The deposits were limited to the interface between the recipient cornea and lenticular lamellar corneal graft, without anterior or posterior extension. There was no anterior chamber reaction noted. As the corneal edema resolved, the deposits became more prominent on slitlamp examination (Figure 1). Subjectively, the patient denied any associated symptoms. A short trial of intensive steroids (from 4 times initially to 8 times per day) was tried without any evidence of deposit appearance.
Case 1. Slitlamp biomicroscopy revealed significant characteristic interface wavelike deposit accumulation.
At the 3-month postoperative examination, the interface deposits remained stable. Despite complete resolution of the corneal edema, the patient's uncorrected and BSCVAs did not improve (20/70). One year after DSAEK, the interface deposits remained unchanged and there was no improvement in the patient's visual acuity.
An 88-year-old man with Fuchs endothelial dystrophy had DSAEK in the left eye for bullous keratopathy after cataract surgery and trabeculectomy in 1997. Preoperatively, the BSCVA in this eye was 20/200. On the first postoperative day, characteristic interface wavelike deposit accumulation was visualized on slitlamp examination despite corneal edema (Figure 2). A short trial of intensive steroids (from 4 times initially to 8 times per day) was tried without any evidence of deposit appearance. No evidence of interface fluid was found using anterior segment optical coherence tomography (Visante; Carl Zeiss Meditec, Dublin, California).
Case 2. Interface wavelike deposits accumulate immediately (A) and 1 month after (B) Descemet stripping endothelial keratoplasty.
At the 1-year follow-up examination, interface deposits remained stable. Despite complete resolution of the corneal edema, the patient's uncorrected and best spectacle-corrected visual acuity did not improve (20/200).
In this case series, we present a post-DSAEK complication that has not previously been described in the literature. Characteristic interface accumulation of wavelike deposits without anterior or posterior extension were present in both patients immediately after DSAEK. The patients' uncorrected and best spectacle-corrected visual acuities remained unchanged (compared with preoperative measurements), even after corneal edema had resolved.
The morphologic features, distribution, and density of these particles remained unaltered throughout the 1-year postoperative observation period. The etiology of these deposits is uncertain. Initially, the possibility of an infectious etiology, intralamellar keratitis, or the development of epithelial downgrowth at the interface space were considered. However, the immediate appearance of the deposits on postoperative day 1, wide extension of the deposits, absence of anterior chamber reaction, lack of improvement after an intensive course of steroids, and unaltered appearance at follow-up visits supported an noninfectious etiology and excluded the possibility of epithelial downgrowth.
Precipitates from the storage media may be a possible source of these deposits/debris. In addition, talc from surgical gloves has been associated with particle deposition. Another possible source is microkeratome or blade debris. Previous studies during laser in situ keratomileusis have demonstrated that the oscillating microkeratome and blade could produce debris that remains at the flap interface.4,5However, these interface deposits did not significantly affect corneal wound healing and remained unreactive and stable during the follow-up periods. The uncorrected and best-corrected visual acuities of both patients were significantly affected, showing no postoperative improvement. In these cases, meticulous rinsing of the stromal interface after flap creation in the eye banks or before injection into the anterior chamber may minimize deposit accumulation.
A major limitation of this study is the lack of confocal or tissue microscopy analysis of the deposits. Future studies including these analyses are needed to elucidate the origin of these deposits.
In conclusion, interface wavelike deposits are an infrequent post-DSAEK complication that could affect patients' final visual outcome. Surgeons and eye banks should be aware of the possibility of this complication after DSAEK.
Correspondence: Dr Kymionis, Institute of Vision and Optics, Department of Ophthalmology, University of Crete Medical School, 71110 Heraklion, Crete, Greece (email@example.com).
Financial Disclosures: None reported.
Kymionis GD, Ide T, Yoo SH. Interface Wavelike Deposits After Descemet Stripping Automated Endothelial Keratoplasty. Arch Ophthalmol. 2009;127(10):1389-1390. doi:10.1001/archophthalmol.2009.249