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Article
September 1969

Aspergillosis of the OrbitReport of Ten Cases and Review of the Literature

Author Affiliations

Washington, DC
From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC. Dr. Green was a Special Fellow in Ophthalmic Pathology, National Institutes of Health, at the Armed Forces Institute of Pathology; he is presently at the Wilmer Ophthalmological Institute, Johns Hopkins Hospital, Baltimore.

Arch Ophthalmol. 1969;82(3):302-313. doi:10.1001/archopht.1969.00990020304002
Abstract

Half of ten cases of orbital aspergillosis occurred in patients in the fourth and fifth decades of life. In four cases, the orbit was secondarily involved, probably from direct extension from the paranasal sinuses. Of five patients who had brain involvement, the primary focus of infection in two was "apparently intracranial," while in three there was secondary involvement of the central nervous system. No evidence of systemic fungal disease was found. The disease presented a protracted clinical course with poor response to local excision of involved tissues and antifungal agents. Six patients are known to have died of the disease; the other four were lost to follow-up. Species of Aspergillus was cultured in four cases. A review of the literature disclosed only 20 previously reported cases.

References
1.
Dalmeijer, J.J.:  Casuïstische Medeceelingen , Nederl T Geneesk 2:2117-2127, 1913.
2.
Wright, R.E.:  Two Cases of Granuloma Invading Orbit Due to an Aspergillus , Brit J Ophthal 11:545-559 ( (Nov) ) 1927.Article
3.
Adams, N.F., Jr.:  Infection Involving the Ethmoid, Maxillary and Sphenoid Sinuses and Orbit Due to Aspergillus Fumigatus , Arch Surg 26:999-1009 ( (June) ) 1933.Article
4.
Nash, C.S.:  Fulminating Infection of Nose Due to Monilia or Aspergillus , Arch Otolaryng 28:234-240 ( (Aug) ) 1938.Article
5.
Veirs, E.R., and Davis, C.T.:  Fungus Infections of Eye and Orbit , Arch Ophthal 59:172-176 ( (Feb) ) 1958.Article
6.
Weller, A.W.; Joseph, D.J.; and Hora, J.F.:  Deep Mycotic Involvement of Right Maxillary and Ethmoid Sinuses, Orbit and Adjacent Structures , Laryngoscope 70:999-1016 (July, (pt 2) ) 1960.Article
7.
Bailey, J.C., and Fulmer, J.M.:  Aspergillosis of Orbit: Report of a Case Treated by Newer Antifungal Antibiotic Agents , Amer J Ophthal 51:670-675 ( (April) ) 1961.
8.
Agarwal, L.P., et al:  Orbital Aspergillosis , Brit J Ophthal 46:559-562 ( (Sept) ) 1962.Article
9.
Seabury, J.H., and Samuels, M.:  The Pathogenetic Spectrum of Aspergillosis , Amer J Clin Path 40:21-33 ( (July) ) 1963.
10.
Agarwal, L.P.; Dayal, Y.; and Agarwal, P.K.:  Radical Excision of a Fungal Granuloma (Aspergillus) of Orbit , Orient Arch Ophthal 2:128-131, 1964.
11.
Satyendran, O.M.; Reddy, P.S.; and Krishnamoorthy, P.:  Fungal Infection of Orbit Manifesting as a Pseudotumor , Orient Arch Ophthal 2:136-137, 1964.
12.
Miloshev, B., et al:  Aspergilloma of Paranasal Sinuses and Orbit in Northern Sudanese , Lancet 1:746-747 ( (April) ) 1966.Article
13.
Townes, D.E.:  Orbital Aspergilloma , Survey Ophthal 12:337-343 ( (Aug) ) 1968.
14.
Emmons, C.W.; Binford, C.H.; and Utz, J.P.: Medical Mycology , Philadelphia: Lea & Febiger, Publishers, 1963, pp 209-211.
15.
Tikhomirov, P.:  Mycosis of Orbit Simulating a Tumor , translated from the Russian, Vestn Oftal 71:44-48, 1958.
16.
Naumann, G.; Green, W.R.; and Zimmerman, L.E.:  Mycotic Keratitis: A Histopathologic Study of 73 Cases , Amer J Ophthal 64:668-682 ( (Oct) ) 1967.
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