[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
November 1969

Effect of Osmotic Agents on the Vitreous Body

Author Affiliations

New York
From the Department of Ophthalmology, New York Medical College, New York.

Arch Ophthalmol. 1969;82(5):694-699. doi:10.1001/archopht.1969.00990020688019

The weight of the rabbit vitreous body is reduced by average clinical doses of hyperosmolar agents. The weight change is 2.7% with orally administered glycerol, and 3.7% and 3.9% with intravenously administered urea and mannitol respectively. This study substantiates the clinical observation that vitreous volume can be reduced by osmotic therapy.

Galin, M.A.; Aizawa, F.; and McLean, J.M.:  Urea as an Osmotic Ocular Hypotensive Agent in Glaucoma , Arch Ophthal 62:347-352 ( (Sept) ) 1959.Article
Weiss, D.I.; Shaffer, R.N.; and Wise, B.L.:  Mannitol Infusion to Reduce Intraocular Pressure , Arch Ophthal 68:341-347 ( (Sept) ) 1962.Article
Virno, M., et al:  Oral Glycerol in Ophthalmology; A Valuable New Method for the Reduction of Intraocular Pressure , Amer J Ophthal 55:1133-1142 ( (June) ) 1963.
Galin, M.A.:  Osmotic Therapy , Ann Inst Barraquer 7:333-338 ( (July-Oct) ) 1966.
Preste, E., and Traverso, G.:  Il meccanismo d'asione del mannitolo: ricerche viscosimetriche sul vitreo di coniglio , Ann Ottal 92:827-836 ( (Oct) ) 1966.
Bucci, M.G.:  Modificazion penderali del vitreo di coniglio dopo somministrazione orale di glicerolo , Boll Oculist 42:569-577 ( (Sept) ) 1963.
Friedenwald, J.S.:  Tonometer Calibration: An Attempt to Remove Discrepancies Found in 1954 Calibration for Schiøtz Tonometers , Trans Amer Acad Ophthal 61:108-123 ( (Jan-Feb) ) 1957.
McBain, E.H.:  Tonometer Calibration , Arch Ophthal 63:936-942 ( (June) ) 1960.Article
Galin, M.A.; Davidson, R.; and Schachter, N.:  Ophthalmological Use of Osmotic Therapy , Amer J Ophthal 62:629-634 ( (Oct) ) 1966.
Becker, B.: " Use of Hyperosmotic Agents in the Treatment of the Glaucomas ," in Symposium on Glaucoma, Transactions of the New Orleans Academy of Ophthalmology , St. Louis: C. V. Mosby Co., 1967, pp 170-174.
Scott, J.M.:  The Use of Urea in Ophthalmology , Amer J Ophthal 53:988-993 ( (June) ) 1962.
Jaffe, N.S., and Light, D.S.:  Treatment of Postoperative Cataract Complications by Osmotic Agents , Arch Ophthal 75:370-374 ( (March) ) 1966.Article
Balazs, E.A.: " Molecular Morphology of the Vitreous Body ," in Smelser, G.K. (ed.): The Structure of the Eye , New York: Academic Press, Inc., 1961, pp 293-310.
Varga, L.:  Studies on Hyaluronic Acid Prepared From the Vitreous Body , J Biol Chem 217:651-658 ( (Dec) ) 1955.
Kinsey, V.E.; Grant, M.; and Cogan, D.G.:  Water Movement and the Eye , Arch Ophthal 27:242-252 ( (Feb) ) 1942.Article
Galin, M.A.; Binkhorst, R.D.; and Kwitko, M.L.:  Ocular Dehydration , Amer J Ophthal 66:233-235 ( (Aug) ) 1968.
Robbins, R., and Galin, M.A.: The Influence of Ocular Massage on Vitreous Mass, Amer J Ophthal, to be published.