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June 1970

Measurements of Aqueous Humor Turnover Rates Using a Gamma Probe

Author Affiliations

Bethesda, Md; Hartford, Conn
From the Ophthalmology Branch, National Institute of Neurological Diseases and Stroke, Bethesda, Md (Dr. Macri), and the Division of Ophthalmology, University of Connecticut Health Center, Hartford, Conn (Dr. O'Rourke).

Arch Ophthalmol. 1970;83(6):741-745. doi:10.1001/archopht.1970.00990030741013

The transcorneal determination of the rate of decay of intracamerally injected iodinated I 125 serum albumin gives an accurate measurement of the rate of aqueous humor formation. The duration of pentobarbital sodium anesthesia had no effect on permeability of the blood-aqueous humor barrier. The blood-aqueous humor barrier, however, did become more permeable to inulin labeled with radioactive carbon (14C) and dextran labeled with radioactive carbon (14C) as a function of elapsed time after the original placements of needles into the anterior chamber. A positive correlation was found between intraocular pressure and the rate of aqueous humor formation in short term experiments. In longer lasting experiments these functions were dissociated.

O'Rourke, J.; Macri, F.J.; and Berghoffer, B.:  Studies in Uveal Physiology: I. Adaptation of Isotope Clearance Procedures for External Monitoring of Anterior Uveal Bloodflow and Aqueous Humor Turnover in the Dog , Arch Ophthal 81:526-533 ( (April) ) 1969.Article
Macri, F.J.; Dixon, R.L.; and Rall, D.L.:  Aqueous Humor Turnover Rates in the Cat: I. Effect of Acetazolamide , Invest Ophthal 4:927-934 ( (Oct) ) 1965.
von Sallmann, L., and Lowenstein, O.:  Responses of Intraocular Pressure and Cutaneous Vessels to Electric Stimulation in the Diencephalon, The Ninth Francis: I. Proctor Lecture , Amer J Ophthal 39:11-29 ( (April) ) 1955.
Gjone, E.; Vance, H.; and Turner, D.A.:  Direct Liquid Scintillation Counting of Plasma and Tissues , Int J Appl Radiat 8:95-97, 1960.Article
Oppelt, W.W., and White, E.D., Jr.:  Effect of Ouabain on Aqueous Humor Formation Rate in Cats , Invest Ophthal 7:328-333, 1968.