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October 1970

Collagenolytic Activity in Experimental Herpes Simplex Keratitis

Author Affiliations

From the Department of Cornea Research, Retina Foundation (Drs. McCulley, Slansky, and Dohlman), the Howe Laboratory of Ophthalmology (Drs. McCulley and Pavan-Langston), Harvard Medical School (Drs. McCulley, Slansky, Pavan-Langston, and Dohlman, and the Massachusetts Eye and Ear Infirmary (Drs. McCulley, Slansky, Pavan-Langston, and Dohlman), Boston.

Arch Ophthalmol. 1970;84(4):516-519. doi:10.1001/archopht.1970.00990040518023

Collagenolytic activity was demonstrated in the epithelium of rabbit corneas experimentally infected with herpes simplex virus in 19 of 20 trephined explants. Control epithelial explants demonstrated minimal to no collagenase activity. This finding may offer one explanation for the stromal ulcerations which can occur in herpetic keratitis. Possible mechanisms of this increased enzyme activity are discussed.

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