The ability of both silk and nylon suture to activate the acute inflammatory pathways was evaluated by comparative γ-globulin binding of the two sutures. Quantitative binding was determined by the amount of radioisotopically labeled IgG was bound by segments of silk and nylon suture; qualitative binding was evaluated by absorption of fluorescein-labeled human γ-globulin and complement. These studies indicated that silk suture has a marked propensity over nylon to bind γ-globulin and that silk suture bound considerably more protein than nylon suture.
Aronson SB, McMaster PRB, Moore TE, Coon MA. The Pathogenesis of Suture Toxicity. Arch Ophthalmol. 1970;84(5):641-644. doi:10.1001/archopht.1970.00990040643017