[Skip to Content]
[Skip to Content Landing]
December 1970

Systemically Administered Anticholinergic Drugs and Intraocular Pressure

Author Affiliations

From the Department of Ophthalmology, University of Tennessee College of Medicine, Memphis.

Arch Ophthalmol. 1970;84(6):735-740. doi:10.1001/archopht.1970.00990040737007

Intraocular pressure (IOP) changes were studied in normal patients, open-angle glaucoma patients, duodenal ulcer patients, and narrow-angle glaucoma patients, along with pupillary changes in response to oral administration of anticholergenic drugs. Of the 48 normal eye studies, in no case was the IOP rise above normal levels. Only 20 of 94 eyes with open-angle glaucoma had an IOP rise of 4 mm Hg or more. In almost every case, the addition of 1% pilocarpine hydrochloride caused the return of the IOP to normal levels. The ulcer patients demonstrated little appreciable change in IOP or pupil size. The narrow-angle glaucoma group showed only three out of 14 eyes to have a significant rise in IOP. All three, however, returned to normal with the use of locally applied pilocarpine.

Leopold IH, Comroe JH:  Effect of intramuscular administration of morphine, atropine, scopolamine, and neostigmine on the human eye . Arch Ophthal 40:285-290, 1948.Article
Schwartz H, et al:  Preanesthetic use of atropine and scopolamine in patients with glaucoma . JAMA 165:144-146, 1957.Article
Tammisto T, et al:  Intramuscularly administered atropine and the eyes . Acta Ophthal 42:408-417, 1964.Article
Mehra KS, Chandra PL:  The effect on the eye of premedication with atropine . Brit J Anaesth 37:133, 1965.Article
Shaffer RN:  Autonomic ocular drugs: Desirable and undesirable effects . Invest Ophthal 3:498-503, 1964.
Lazenby GW, Reed JW, Grant WM:  Short-term tests of anticholinergic medications in open-angle glaucoma . Arch Ophthal 80:443-448, 1968.Article
Grant WM:  Ocular complications of drugs: Glaucoma . JAMA 207:2089-2091, 1969.Article
Mehra KS, Chandra P:  Ocular manifestations of parenteral administration of scopolamine (Myoscine) . Brit J Ophthal 49:557-558, 1965.Article
Mulberger RD:  Effects of a common cold product containing belladonna on I.O.P. Eye Ear Nose Throat Monthly 47:71-73, 1968.
Roth N:  Refractive state after instillation of paredrine and neosynephrine . Brit J Ophthal 52:763-767, 1968.Article
Ullman EV, Mussman FD:  Glaucoma and orally administered belladonna . Northwest Med 48:245-246, 1949.
Gorin G:  Glaucoma induced by prolonged use of atropine . Amer J Ophthal 56:639-641, 1963.
Becker B:  Effect of Phenylephrine on the miotic treated eye . Amer J Ophthal 49:557-558, 1965.
Gholst M, et al:  Glaucoma in medical practice: Danger of use of systemic antispasmodic drugs in patients predisposed to or having glaucoma . JAMA 166:1276-1280, 1958.Article
de Roetth A Jr, Schwartz H:  Aqueous humor dynamics in glaucoma: Effect of ganglionic blocking agents and thiopental sodium (Pentothal) anesthesia on aqueous humor dynamics . Arch Ophthal 55:755-764, 1956.Article
Detorres LM:  Influence of atropine given intravenously on the ocular tension of primary glaucoma , abstracted. Amer J Ophthal 30:1454, 1947.
Bron AJ, Knox DL, Gaasterland D:  Tonographic studies in carotid occlusion disease . Brit J Ophthal 51:577-595, 1967.Article
Hufford AR:  Bentyl hydrochloride: Successful administration of parasympatholytic antispasmodics in glaucoma patients . Amer J Dig Dis 1952, pp 257-258.
Haggerty G:  Glaucoma and G. I. disease: Belladonna induced glaucoma . Georgetown University Medical Center Bulletin 7:50-53, 1954.
Rezzotti R, et al:  Medical therapy attempts in malignant glaucoma: Report of three cases . Amer J Ophthal 57:402-406, 1964.
Bakurinu K, Stepochkinana, Rusakova KC:  Effect of pilocarpine and atropine on pupil size and intraocular pressure in rabbits with normal and impaired inervation of the eye . Fiziol Zh SSSR Sechenov 47:18-21, 1961.
Lowe RF:  Acute angle closure glaucoma precipitated by miotics plus adrenalin eye drops . Med J Aust 2:1037-1038, 1966.
Rosen DF:  Anesthesia in ophthalmology . Canad Anaesth Soc J 9:545, 1962.Article