[Skip to Content]
[Skip to Content Landing]
May 1971

Elevated Heparin-Precipitable Fraction (HPF) in Patients With Uveitis

Author Affiliations

San Francisco
From the Rheumatic Disease Group, departments of medicine (Dr. Epstein) and ophthalmology (Dr. Balis), University of California, San Francisco.

Arch Ophthalmol. 1971;85(5):548-552. doi:10.1001/archopht.1971.00990050550005

Thus far, there has been no demonstration of a systemic factor which reflects the inflammatory process in idiopathic uveitis. In evaluating 103 patients with uveitis and no other apparent illness, we found that many of these patients had significantly higher levels of heparin-precipitable fraction (HPF) in their plasma (141 ± 75 mg/100 cc) than normal individuals (50 ± 20 mg/100 cc) or patients with nonuveitis eye disease ( 55 ± 33 mg/100 cc). Most of these patients had normal erythrocyte sedimentation rates. Heparin-precipitable fraction is a cryoprecipitable fibrinogenheparin complex found in heparinized plasma, believed to be formed as a result of activation of the clotting mechanism. There was no correlation between HPF levels and the type of uveitis, degree of observed inflammatory activity, or method of treatment.

Wolkowicz MI, Hallett JW, Leopold IH, et al:  Nonspecific tests in uveitis . Amer J Ophthal 48:502-510, 1959.
Schlaegel TF Jr, Weber JC:  The sedimentation rate in endogenous uveitis . Arch Ophthal 73:657-658, 1965.Article
Thomas L, Smith RT, von Korff RW:  Cold-precipitation by heparin of a protein in rabbit and human plasma . Proc Soc Exp Biol Med 86:813-818, 1954.Article
Smith RT, von Korff RW:  A heparin precipitable fraction of human plasma: I. Isolation and characterization of the fraction . J Clin Invest 36:596-604, 1957.Article
Smith RT:  A heparin precipitable fraction of human plasma: II. Occurrence and significance of the fraction in normal individuals and in various disease states . J Clin Invest 36:605-616, 1957.Article
Ruiter M:  Possible connection between abnormal plasma fraction (HPF) and vascular fibrinoid in arteriolitis (vasculitis) "allergica" cutis . J Invest Derm 38:117-121, 1962.
Cotton RC, Johnson FL:  Plasma antiheparin activity and the heparin precipitable fraction of plasma in rheumatoid arthritis . Ann Rheum Dis 27:425-430, 1968.Article
Rivero I, Ritz ND:  Abnormal fibrinogen in thrombotic thrombocytopenic purpura . Blood 32:140-147, 1968.
Shainoff JR, Page IH:  Cofibrins and fibrin intermediates as indicators of thrombin activity in vivo . Circ Res 8:1013-1022, 1960.Article
Shainoff JR, Page IH:  Significance of cryoprofibrin in fibrinogen-fibrin conversion . J Exp Med 116:687-707, 1962.Article
Hogan M, Kimura S, Thygeson P:  Signs and symptoms of uveitis . Amer J Ophthal 47:155-170, 171-176, 1959.
Ratnoff O, Menzie C:  A new method for the determination of fibrinogen in small samples of plasma . J Lab Clin Med 37:316-320, 1951.
McKay DG: Disseminated Intravascular Coagulation . New York, Harper & Row, 1965, p 376.
Mosseson MW, Colman RW, Sherry S:  Chronic intravascular coagulation syndrome . New Eng J Med 278:815-821, 1968.Article
Pindyck J, Lichtman HC, Schuyler GK:  Cryofibrinoginemia in women using oral contraceptives . Lancet 1:51-53, 1970.Article
Craig JM, Gitlin D:  Distribution of fibrin in human pathologic lesions using labeled fluorescent antifibrin serum . Fed Proc 14:401, 1955.
Maumenee AE, Silverstein AM: Immunopathology of Uveitis . Baltimore, Williams & Wilkins, 1964.
Dixon FJ Jr, Kunkel GH: Advances in Immunology . New York, Academic Press, 1969, pp 186-188.