[Skip to Content]
[Skip to Content Landing]
Article
July 1972

Pathological Condition of the Retinal Pigment EpitheliumNeoplasms and Nodular Non-neoplastic Lesions

Author Affiliations

USA, Washington, DC; New Haven, Conn
From the Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, and the Department of Ophthalmology, the George Washington University Medical Center, Washington, DC (Dr. Tso), and the Section of Ophthalmology, Yale University School of Medicine, New Haven, Conn (Dr. Albert).

Arch Ophthalmol. 1972;88(1):27-38. doi:10.1001/archopht.1972.01000030029007
Abstract

Eleven primary neoplasms of the retinal pigment epithelium (RPE) were studied histopathologically. These tumors presented a variety of histologic patterns, namely mosaic, tubular, papillary, or a patternless arrangement of vacuolated or anaplastic cells. The tumor with the mosaic pattern was regarded as best differentiated, the anaplastic tumor the least differentiated, and the tumors with vacuolated cells or tubular or papillary patterns in the middle of the spectrum. Such tumors invaded the retina and choroid, but metastasis was not observed. These neoplasms were contrasted with six nodular reactive proliferations of RPE, one of which approached neoplasia. Histologic criteria for differentiation of neoplasia from reactive proliferation are discussed. The available clinical data on tumors of the RPE and on reactive lesions are analyzed and compared.

References
1.
Martens M:  Eine primäre bösartige epitheliale Geschwulst des Augeninnern bei Erwachsenen . Arch Augenheilk 85:1-22, 1921.
2.
Schuster H:  Retinoepithelioma malignum pigmentosum . Virchow Arch Path Anat 269:97-104, 1928.Article
3.
Bietti G:  Ueber ein vom Pigmentepithel ausgehendes Melanokarzinom des Bulbus und der Orbita . Klin Mbl Augenheilk 87:459-486, 1931.
4.
Stow MN:  Hyperplasia of the pigment epithelium of the retina simulating a neoplasia . Trans Amer Acad Ophthal Otolaryng 53:674, 1949.
5.
Theobold GD, Ford GJ, Kirk HG:  Hyperplasia of retinal pigment epithelium simulating a neoplasm: Report of two cases . Amer J Ophthal 45:235-240, 1958.
6.
Duke JR, Maumenee AE:  An unusual tumor of the retinal pigment epithelium . Amer J Ophthal 47:311-317, 1959.
7.
Kornblueth W, Beher AJ:  Hyperplasia of the pigment epithelium of the retina simulating a malignant melanoma . Israel Med J 19:237-240, 1960.
8.
Kurz GH, Zimmerman LE:  Vagaries of the retinal pigment epithelium . Int Ophthal Clin 2:441, 1962.Article
9.
Frayer WC:  Reactivity of the retinal pigment epithelium: An experimental and histopathologic study . Trans Amer Ophthal Soc 64:586, 1966.
10.
Greer CH:  Epithelial tumors of the retinal pigment epithelium . Trans Ophthal Soc UK 72:265-277, 1952.
11.
Fair JR:  Tumor of the retinal pigment epithelium . Amer J Ophthal 45:495-505, 1958.
12.
Reese AB:  The role of the pigment epithelium in ocular pathology . Amer J Ophthal 50:1066-1084, 1960.
13.
Blodi FC, Reuling FH, Sornson ET:  Pseudomelanocytoma at the optic nervehead: An adenoma of the retinal pigment epithelium . Arch Ophthal 73:353-355, 1965.Article
14.
Garner A:  Tumors of the retinal pigment epithelium . Brit J Ophthal 54:715, 1970.Article
15.
Reese AB: Tumors of the Eye , ed 2. New York, Paul B Hoeber, 1963, p 46.
16.
Albert DM, Rabson AS, Dalton AJ:  In vitro neoplastic transformation of uveal and retinal tissue by oncogenic DNA virus . Invest Ophthal 7:357-365, 1968.
×