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Article
November 1972

Collagen Vitreous SubstituteI. Experimental Study

Author Affiliations

Boston
From the Department of Retina Research, Retina Foundation, and the Retina Service, Massachusetts Eye and Ear Infirmary, Boston. Dr. Calabria is now with the Clinica Oculistica, Universita di Genova, Italy.

Arch Ophthalmol. 1972;88(5):540-543. doi:10.1001/archopht.1972.01000030542015
Abstract

Proctase-treated collagen vitreous substitutes were evaluated in monkey eyes. Nonirradiated viscous collagen solutions formed cloudy white opacities immediately after injection into the vitreous cavity. The vitreous turbidity did not completely clear during two years of observation. Collagen gels, formed by ultraviolet irradiation of collagen solutions, remained clear after injection but lacked the rigidity desired for retinal detachment surgery. The solutions and gels both produced a transient inflammatory response, but no destructive sequelae were noted.

References
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Dunn MW, Stenzel KH, Rubin AL, et al:  Collagen implants in the vitreous . Arch Ophthal 82:840-844, 1969.Article
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Rubin AL, Riggio RR, Nachman RL, et al:  Collagen materials in dialysis and implantation . Trans Amer Soc Artif Intern Organs 14:169-175, 1968.
3.
Stenzel KH, Dunn MW, Rubin AL, et al:  Collagen gels: Design for a vitreous replacement . Science 164:1282-1283, 1969.Article
4.
Johnson GL:  Contributions to the comparative anatomy of the mammalian eye chiefly based on ophthalmoscopic examination . Phil Trans Roy Soc 166: 474-478, 1900.
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