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To the Editor.
—The article by Drs. Shields and Font illustrates very well two extremely important facts. (1) No one, no matter what degree of experience, can look at a fundus lesion and say with certainty that it is or is not malignant. (2) There is nothing specific about the fluorescein angiographic findings seen in malignant melanoma of the choroid, and the angiographic findings are of relatively little help in establishing the malignant nature of a given fundus lesion.There is a test which is specific for malignancy—32P testing. The 32P particle is assimilated into the nuclear protein of rapidly mitotic cells and hence is specific for malignant tissue. The test will not differentiate the type of malignancy.Although the past literature is replete with reports of false-positive and false-negative readings, these are easily explainable on the basis of inadequate instrumentation and poor technique, including interpretation. Done
Ruiz RS. FURTHER COMMENTS ON MALIGNANT MELANOMA. Arch Ophthalmol. 1972;88(6):696. doi:10.1001/archopht.1972.01000030698027