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Article
February 1973

Factors Affecting Tear Film Breakup in Normal Eyes

Author Affiliations

Washington, DC
From the Cornea Service, Georgetown University Medical Center, Washington, DC.

Arch Ophthalmol. 1973;89(2):103-105. doi:10.1001/archopht.1973.01000040105007
Abstract

Tear film breakup time (BUT) was measured in 50 normal subjects. The reproducibility of this value, its relationship to age and sex, the effects of lid holding, and the instillation of a local anesthetic were studied. Results have defined a range of normal values and indicate that holding the lids and the instillation of a local anesthetic significantly reduce BUT. No relationship between BUT and age, sex, or corneal sensation was noted. Breakup time is a reproducible phenomenon in an individual eye.

References
1.
Wolff E: Anatomy of the Eye and Orbit , ed 4. New York, Blakiston Co, 1954,pp 207-209.
2.
Lemp MA, et al:  The precorneal tear film: Factors in spreading and maintaining a continuous tear film over the corneal surface . Arch Ophthalmol 83:89-94, 1970.Article
3.
Holly FJ, Lemp MA:  Wettability and wetting of the corneal epithelium . Exp Eye Res 11:239-251, 1971.Article
4.
Haen GI, Marx E:  Sur le desséchement de la corneé . Ann Ocul 163:334-358, 1921.
5.
Rollet J:  La couche de liquide pré-cornéene . Arch Ophthalmol 53:111, 255, 1936.
6.
Norn MS:  Desiccation of the precorneal tear film: I. Corneal wetting time . Acta Ophthalmol 47:865-880, 1969.Article
7.
Brown SI:  Further studies on the pathophysiology of keratitis sicca of Rollet . Arch Ophthalmol 83:542-547, 1970.Article
8.
Lemp MA, Dohlman CH, Holly FJ:  Corneal desiccation despite normal tear volume . Ann Ophthalmol 2:258-284, 1970.
9.
Lemp MA, et al:  Dry eye secondary to mucus deficiency . Trans Am Acad Ophthalmol Otolaryngol 75:1223-1227, 1971.
10.
Doughman D, Holly FJ, Dohlman CH: Preliminary studies on the stability of aqueous films on solids. Read before the spring meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, 1971.
11.
Duke-Elder S: System of Ophthalmology . St. Louis, CV Mosby Co, 1962, vol 7, p 594.
12.
Pfister RR, Holly FJ, Kuwabara T: Factors affecting cell wall morphology of corneal epithelium. Read before the spring meeting of the Association for Research in Vision and Ophthalmology, Sarasota, Fla, 1972.
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