Acute ocular inflammation was produced in rabbits previously sensitized to horse serum by intraocular injection of horse serum. Aqueous suspensions of oxyphenbutazone in varying concentrations were applied to these eyes under double-blind conditions every hour for eight hours. This agent was found to exhibit anti-inflammatory action in concentrations of 1% and 0.5%, but not 0.25%.
Thomas AH, Hanna C. Oxyphenbutazone in Ocular Inflammation. Arch Ophthalmol. 1973;89(4):340-341. doi:10.1001/archopht.1973.01000040342017