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Article
September 1973

Octafluorocyclobutane and Other Gases for Vitreous Replacement

Author Affiliations

Chicago
From the Department of Ophthalmology, University of Illinois Abraham Lincoln School of Medicine and the Eye and Ear Infirmary of the University of Illinois Hospital, Chicago.

Arch Ophthalmol. 1973;90(3):235-236. doi:10.1001/archopht.1973.01000050237011
Abstract

In this study, an attempt was made to find a nontoxic gas for vitreous replacement that would be more slowly reabsorbed than air. One-tenth milliliter of air, helium, neon, argon, krypton, xenon, sulfur hexafluoride, and octafluorocyclobutane (Freon-C318) were injected into rabbit eyes. Octafluorocyclobutane, an insoluble gas of high molecular weight, remained the longest, an average of 7.47 days compared to 1.72 days for air. Ophthalmoscopic and histologic examination of two of the octafluorocyclobutane-injected eyes showed no evidence of toxic reaction. Inexpensive and readily available, octafluorocyclobutane merits further experimental study, particularly for use in retinal detachment surgery.

References
1.
Deutschman R:  Zur operativen Behandlung der Netzhautablösung . Klin Monatsbl Augenheilkd 44:364-370, 1906.
2.
Ohm J:  Über die Behandlung der Netzhautablösung durch operative Entleerung der subretinalen Flussigkeit und Einspritzung von Luft in den Glaskörper. Albrecht von Graefes Arch Ophthalmol 79:442-450, 1911.
3.
Elschnig A:  Uber Glaskörperersatz II. Teil Albrecht von Graefes Arch Ophthalmol 80:514-536, 1912.
4.
Cutler NL:  Transplantation of human vitreous: A preliminary report . Arch Ophthalmol 35:615-623, 1946.Article
5.
Schafer DM:  The treatment of retinal detachment by vitreous implant . Trans Am Acad Ophthalmol Otolaryngol 61:194-200, 1957.
6.
Fritz MH, Fennessy TM, Cabrera H:  Operative technique of vitreous replacement . Am J Ophthalmol 30:1221-1224, 1947.
7.
Okun E:  Intravitreal surgery utilizing liquid silicone: A long-term follow-up . Trans Pac Coast Otoophthalmol Soc 49:141-159, 1968.
8.
Watzke RC:  Silicone retinopiesis for retinal detachment: A long-term clinical evaluation . Arch Ophthalmol 77:185-196, 1967.Article
9.
Hruby K:  Hyaluronsäure als Glaskörpersatz bei Netzhautablösung . Klin Monatsbl Augenheilkd 138:484-496, 1961.
10.
Hruby K:  Physiologischer Glaskörperersatz . Wien Klin Wochenschr 79:480-483, 1967.
11.
Rosengren B:  Cases of retinal detachment treated with diathermy and injection of air into the vitreous body . Acta Ophthalmol 16:177, 1938.
12.
Rosengren B:  Air injection in retinal detachment , in Acta XVI Concilium of Ophthalmolicum Brittannia 1950 . London, British Medical Association, 1951, pp 1212-1217.
13.
Rosengren B:  300 cases operated upon for retinal detachment . Acta Ophthalmol 30:17-122, 1952.
14.
Arruga H:  Certain consideration of the surgical treatment of retinal detachment . Am J Ophthalmol 35:1573-1580, 1952.
15.
Norton EWD, et al:  Giant retinal tears: I. Clinical management with intravitreal air . Am J Ophthalmol 68:1011-1021, 1969.
16.
Machemer R, Aaberg TM, Norton EWD:  Giant retinal tears: II. Experimental production and management with intravitreal air . Am J Ophthalmol 68:1022-1029, 1969.
17.
Schenk H:  Experimentelle und klinische Untersuchgen zur Frage der Resorption gasförmiger Stoffe aus dem Glaskörper . Albrecht von Graefes Arch Ophthalmol 161:252-281, 1959.Article
18.
Widder W:  Tierversuche über die Verweildauer verschiedener Glaskörperimplantate . Albrecht von Graefes Arch Ophthalmol 164:550-569, 1962.Article
19.
Edelhauser HF, Aaberg TM, Van Horn DL: Effects of sulfahexafluoride gas on the rabbit cornea. Read before the Association for Research in Vision and Ophthalmology Meeting, Sarasota, Florida, 1972.
20.
Fineberg E, et al: Observations on the behavior of intravitreal sulfur hexafluoride in owl monkeys. Read before the Association for Research in Vision and Ophthalmology Meeting, Sarasota, Florida, 1972.
21.
Stecher PG, et al (eds): Merck Index of Chemicals and Drugs , ed 7. Rahway, NJ, Merck & Co Inc, 1960, pp 741, 1003.
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