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January 1974

Ocular Blood Flow in Experimentally Induced Immunogenic Uveitis

Author Affiliations

San Francisco
From the Eyetis Foundation (Dr. Aronson) and the departments of ophthalmology (Drs. Howes and O'Day), pathology (Dr. Howes), and clinical pathology and laboratory medicine (Drs. Fish and Pollycove), University of California Medical Center, San Francisco.

Arch Ophthalmol. 1974;91(1):60-65. doi:10.1001/archopht.1974.03900060064016

The subsequent study has evaluated ocular blood flow during several stages of experimentally induced immunogenic uveitis in rabbits. Blood flow was measured following intracardiac injection of carbonized microspheres (25μ±5μ) labeled with strontium chloride Sr 85. In acute or chronic mild inflammation, ocular blood flow is elevated. In severe acute Inflammation, ocular blood flow is markedly diminished. This decrease correlates with the presence of an extensive uveal vasculitis and thromboses primarily in choroidal blood vessels and helps explain on a pathogenetic basis some of the phenomena encountered in uveitis.

Aronson SB, Elliott JH: Ocular Inflammation . St. Louis, CV Mosby Co, 1972.
Aronson SB, et al:  Pathogenetic approach to therapy of peripheral corneal inflammatory disease . Am J Ophthalmol 70:65-90, 1970.
Aronson SB, et al:  Corticosteroids in infectious ocular disease , in Kaufman HE (ed): Ocular Anti-inflammatory Therapy . Springfield, Ill, Charles C Thomas Publisher, 1970, pp 14-29.
Aronson SB, et al:  Corticosteroid therapy in metastatic endophthalmitis . Arch Ophthalmol 85:61-70, 1971.Article
Levine RE, Ward PA:  Experimental acute immunologic ocular vasculitis . Am J Ophthalmol 69:1023-1031, 1970.
O'Rourke J, Macri FJ:  Studies in uveal physiology: II. Clinical studies of the anterior chamber clearance of isotopic tracers . Arch Ophthalmol 84:415-420, 1970.Article
O'Day DM, et al:  Ocular blood flow measurement by nuclide labeled microspheres . Arch Ophthalmol 86:205-209, 1971.Article
Rudolph AM, Heymann MA:  The circulation of the fetus in utero . Circ Res 21:163-184, 1967.Article
Jensen PR, et al:  Mechanisms of the host response in the eye: III. Interocular antigen transfer . Arch Ophthalmol 77:814-817, 1967.Article
Silverstein AM, Zimmerman LE:  Immunologic experimental endophthalmitis produced in the guinea pig by different pathogenetic mechanisms . Am J Ophthalmol 48:435-447, 1959.