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Article
February 1974

Pilocarpine and Intraocular PressureDuration of Effectiveness of 4% and 8% Pilocarpine Instillation

Author Affiliations

Vancouver, British Columbia, Canada
From the Department of Ophthalmology, University of British Columbia, the Glaucoma Clinic, Vancouver General Hospital and the Department of Ophthalmology, Shaughnessy Hospital, Department of Veterans Affairs Hospital, Vancouver, British Columbia, Canada.

Arch Ophthalmol. 1974;91(2):104-106. doi:10.1001/archopht.1974.03900060110004
Abstract

The duration of effectiveness of single instillations of 4% and 8% pilocarpine in one eye of a number of patients with ocular hypertension was observed. Both 4% and 8% pilocarpine were still effective in lowering intraocular pressure at the end of 12 hours, after which time the pressures started to rise. A statistically significant drug effect still persisted 15 hours after administration.

References
1.
Drance SM, Nash PA:  The dose response of human intraocular pressure to pilocarpine . Can J Ophthalmol 6:9-13, 1971.
2.
Harris LS, Galin MA:  Dose response analysis of pilocarpine-induced ocular hypotension . Arch Ophthalmol 84:605-608, 1970.Article
3.
Anderson PA, Cowle JB:  Influence of pH on the effect of pilocarpine on aqueous dynamics . Br J Ophthalmol 52:607-611, 1968.Article
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