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Article
June 1974

Acute Optic NeuropathyTreatment With Diphenylhydantoin

Author Affiliations

St. Louis
From the Department of Ophthalmology, Washington University School of Medicine, St. Louis. Dr. Ellenberger is a Fellow in Neuro-ophthalmology.

Arch Ophthalmol. 1974;91(6):435-438. doi:10.1001/archopht.1974.03900060449003
Abstract

Previous reports have suggested that diphenylhydantoin may improve visual field loss resulting from ischemic disease of the optic nerves. Therefore, 15 patients with residual visual impairment after acute, presumably ischemic, optic neuropathy were treated alternately with diphenylhydantoin sodium and placebo in a double-blind study. Neither visual acuity nor visual fields improved during treatment. The importance of careful quantitative perimetry with preliminary repetitive testing until results are reproducible is stressed.

References
1.
Bassett AL, Bigger JT, Hoffman BF:  "Protective" action of DPH on canine Purkinje fibers during hypoxia . J Pharmacol Exp Ther 173:336-343, 1970.
2.
Becker B, et al:  Effect of diphenylhydantoin on glaucomatous field loss: A preliminary report . Trans Am Acad Ophthalmol Otolaryngol 76:412-422, 1972.
3.
Keltner JL, et al:  Effect of diphenylhydantoin in ischemic optic neuritis . Trans Am Ophthalmol Soc 70:113-129, 1972.
4.
Ellenberger C, Keltner JL, Burde RM:  Acute optic neuropathy in older patients . Arch Neurol 28:182-185, 1973.Article
5.
Aulhorn E, Harms H:  Visual perimetry , in Jameson D, Hurvich LM (eds): Handbook of Sensory Physiology . Berlin, Springer-Verlag, 1972, vol 7, pp 102-145.
6.
Harms H:  Die Technik der statischen Perimetrie . Ophthalmologica 158:387-405, 1969.Article
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