[Skip to Content]
[Skip to Content Landing]
Article
July 1974

Photodynamic Inactivation of Herpes Simplex Keratitis

Author Affiliations

Winston-Salem, NC
From the departments of ophthalmology and microbiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC.

Arch Ophthalmol. 1974;92(1):51-53. doi:10.1001/archopht.1974.01010010055013
Abstract

Bilateral herpes simplex keratitis was induced in rabbit corneas. The infected corneas were treated with either neutral red dye followed by exposure to fluorescent light or with idoxuridine ointment. Dye-light treatment produced a faster cure rate than idoxuridine.

References
1.
Spikes JD, Livingston R:  The molecular biology of photodynamic action: sensitized photoautoxidation in biologic systems . Adv Radiation Biol 3:29-121, 1969.
2.
Raab OZ:  Über die wirking fluoreszierender staffe auf infusorien . Z Biol 39:524-546, 1900.
3.
Wallis C, Melnick JL:  Photodynamic inactivation of animal viruses: A Review . Photochem Photobiol 4:159-170, 1965.Article
4.
Wallis C, Melnick JL:  Irreversible photosensitization of viruses . Virology 23:520-527, 1964.Article
5.
Freifelder D, Uretz RB:  Mechanism of photoinactivation of coliphage T7 sensitized by acridine orange . Virology 30:97-103, 1966.Article
6.
Felber TD, et al: Photodynamic inactivation of herpes simplex. Read before the Scientific Assembly AMA Section of Dermatology, Atlantic City, NJ, 1971.
7.
Moore C, et al:  Photodynamic treatment of herpes keratitis . Infect Immun 5:169-171, 1972.
8.
Hiatt CW, et al:  Inactivation of viruses by the photodynamic action of toluidine blue . J Immunol 84:480-484, 1960.
9.
Kaufman HE, Nesburn AB, Maloney EB:  IDU therapy of herpes simplex . Arch Ophthalmol 67:583-591, 1967.Article
10.
Sastry KS, Gordon MP:  The photodynamic inactivation of tobacco mosaic virus and its ribonucleic acid by acridine orange . Biochim Biophys Acta 129:32-41, 1966.Article
11.
Kobayashi S, Nakamura T:  Development of IDU-resistant herpes simplex virus , abstracted. Acta Soc Ophthalmol Jap 67:1685-1686, 1963.
12.
Nesburn AB, Cook ML, Stevens JG:  Latent herpes simplex virus . Arch Ophthalmol 88:412-417, 1972.Article
13.
Roizman B:  An inquiry into the mechanisms of recurrent herpes infections in man , in Pollard M (ed): Gustav Stern Symposium on Perspectives in Virology . New York, Harper and Row, 1965, vol 4.
×