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Article
September 1974

Experimental Corneal Wound StrengthEffect of Topically Applied Corticosteroids

Author Affiliations

From the Department of Ophthalmology, College of Medicine, University of Florida, Gainesville. Dr. Sugar is now with the Department of Ophthalmology, Washington University School of Medicine, St. Louis. Dr. Chandler is now with the Department of Ophthalmology, University of Washington, Seattle.

Arch Ophthalmol. 1974;92(3):248-249. doi:10.1001/archopht.1974.01010010256018
Abstract

Dexamethasone, 0.1%, was administered topically to rabbits three times daily at various intervals after they sustained central corneal wounds. The eyes treated during the first postoperative week demonstrated significantly diminished wound tensile strength compared to either the contralateral eyes or untreated controls. Eyes treated during the third postoperative week had no reduction in corneal wound tensile strength.

References
1.
Gasset AR, et al:  Quantitative corticosteroid effect on corneal wound healing . Arch Ophthalmol 81:589-591, 1969.Article
2.
Lorenzetti DWC, et al:  Subconjunctival corticosteroids: Effects on corneal xenograft reaction and wound healing . Can J Ophthalmol 7:42-47, 1972.
3.
Leopold IH, et al:  Local and systemic cortisone in ocular disease . Am J Ophthalmol 34:361-371, 1951.
4.
Newell FW, Dixon JM:  Effect of subconjunctival cortisone upon the immediate union of experimental corneal grafts . Am J Ophthalmol 34:977-982, 1951.
5.
Ashton N, Cook C:  Effect of cortisone on healing of corneal wounds . Br J Ophthalmol 35:708-717, 1951.Article
6.
Palmerton ES:  The effect of local cortisone on wound healing in rabbit corneas . Am J Ophthalmol 40:344-353, 1955.
7.
Basu PK:  Effect of different steroids on the healing of nonperforating corneal wounds in rabbits . Arch Ophthalmol 59:657-664, 1958.Article
8.
Fink AI, Baras I:  Effect of steroids on tensile strength of corneal wounds . Am J Ophthalmol 42:759-764, 1958.
9.
Aquavella JV, Gasset AR, Dohlman CH:  Corticosteroids in corneal wound healing . Am J Ophthalmol 58:621-626, 1964.
10.
Kara-José N, et al:  Time response effects of corticosteroids on corneal wound healing . Can J Ophthalmol 7:48-51, 1972.
11.
Gasset AR, Dohlman CH:  The tensile strength of corneal wounds . Arch Ophthalmol 79:595-602, 1968.Article
12.
Chandler JW, Sugar J, Gasset AR:  Experimental corneal wound strength: 7-0 silk versus 10-0 monofilament nylon . Arch Ophthalmol 92:155-156, 1974.Article
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