[Skip to Content]
[Skip to Content Landing]
Article
January 1975

Intravitreal Injection of Cephaloridine in the Treatment of Endophthalmitis

Author Affiliations

From the Department of Ophthalmology, University of Illinois Eye and Ear Infirmary, Chicago.

Arch Ophthalmol. 1975;93(1):56-61. doi:10.1001/archopht.1975.01010020060011
Abstract

Ocular toxic effects of intravitreal injection of cephaloridine in rabbits was evaluated, and none were produced in doses of 0.25 mg or less.

Clinically, intravitreal injection of cephaloridine in doses of 5 mg or more produced small punctate hemorrhages in the vascularized portions of the rabbit retina within two days. With doses of 2.5 mg or less, no clinical changes were seen during the two weeks of observation.

Histologically, one day following intravitreal injection of 0.5 to 10 mg of cephaloridine there was clumping of the outer segments of the photoreceptors and destruction of the retinal pigment epithelium.

Ten milligrams of cephaloridine intravitreally injected caused definite electroretinogram (ERG) changes ten minutes after injection. After 24 hours, the ERG was extinguished.

An experimentally induced Escherichia coli endophthalmitis was successfully treated after six hours by intravitreal injection of cephaloridine.

References
1.
von Sallman L, Meyer K, Di Grandi J:  Experimental study on penicillin treatment of ectogenous infection of vitreous . Arch Ophthalmol 32:179-189, 1944.Article
2.
von Sallman L:  Controversial points in penicillin therapy for ocular diseases . Arch Ophthalmol 39:752-804, 1948.Article
3.
Leopold IH:  Intravitreal penetration of penicillin and penicillin therapy of infections of vitreous . Arch Ophthalmol 33:211-216, 1945.Article
4.
Maylath FR, Leopold IH:  A study of intraocular infection . Am J Ophthalmol 40:86-101, 1955.
5.
Mann I:  The intraocular use of penicillin . Br J Ophthalmol 30:134-146, 1946.Article
6.
Duguid JP, Ginsberg M, Fraser IC, et al:  Experimental observation on the intravitreous use of penicillin and other drugs . Br J Ophthalmol 31:193-211, 1947.Article
7.
Ellis PP, Smith DL:  Therapy of intraocular infection , in Handbook of Ocular Therapeutics and Pharmacology , ed 3. St. Louis, CV Mosby Co, 1969, pp 104-110.
8.
Peyman GA, May DR, Ericson ES, et al: Intraocular injection of gentamicin: Toxic effects and clearance. Arch Ophthalmol, to be published.
9.
Graham RO, Peyman GA: Intravitreal injection of dexamethasone in experimentally induced endophthalmitis. Arch Ophthalmol, to be published.
10.
May DR, Ericson ES, Peyman GA, et al:  Intraocular injection of gentamicin: Single injection therapy of experimental bacterial endophthalmitis . Arch Ophthalmol 91:487-489, 1974.Article
11.
Daily MJ, Peyman GA, Fishman G:  Intravitreal injection of methicillin for treatment of endophthalmitis . Am J Ophthalmol 76:343-350, 1973.
12.
Records RR:  Intraocular penetration of cephaloridine: Observations in experimental animal and human eyes . Arch Ophthalmol 81:331-335, 1969.Article
×