In 27 cases of invasive conjunctival squamous cell carcinoma, three cases of deep corneal invasion and two cases of intraocular extension were found. Four cases showed orbital invasion, and one patient died of generalized metastases 18 months after diagnosis. The relatively low-grade nature of these lesions and their potential for local treatment is noted, but it is emphasized that careful clinical examination and close cooperation with the pathologist to ensure adequate evaluation of excised tissue are essential.
Iliff WJ, Marback R, Green WR. Invasive Squamous Cell Carcinoma of the Conjunctiva. Arch Ophthalmol. 1975;93(2):119-122. doi:10.1001/archopht.1975.01010020125005