[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.211.41.181. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 1976

Cornea and Sclera

Author Affiliations

From the Cornea Service, Department of Ophthalmology, Georgetown University Medical Center, Washington, DC.

Arch Ophthalmol. 1976;94(3):473-490. doi:10.1001/archopht.1976.03910030239014
References
1.
Lemp MA:  Cornea and sclera . Arch Ophthalmol 92:158-170, 1974.Article
2.
Friedenwald JS, Buschke W:  Influence of some experimental variables on the epithelial movements in the healing of corneal wounds . J Cell Comp Physiol 23:95-107, 1944.Article
3.
Arey LB, Covode WN:  The method of repair in epithelial wounds of the cornea . Anat Rec 86:75-86, 1943.Article
4.
Buschke WH:  Morphologic changes in cells of corneal epithelium in wound healing . Arch Ophthalmol 41:306-316, 1949.Article
5.
Hanna C, O'Brien JE:  Cell production and migration in the epithelial layer of the cornea . Arch Ophthalmol 64:536-539, 1960.Article
6.
Hanna C:  Proliferation and migration of epithelial cells during corneal wound repair in the rabbit and the rat . Am J Ophthalmol 61:55-63, 1966.
7.
Krejci L, Harrison R:  Epinephrine effects on corneal cells in tissue culture . Arch Ophthalmol 83:451-454, 1970.Article
8.
van Alphen GWHM:  Acetylcholine synthesis in corneal epithelium . Arch Ophthalmol 58:449-451, 1957.Article
9.
Gnädinger M:  Die acetylcholine-spaltungsfähigkeit des epithels der kaninchen hornhaut . Ophthalmologica 154:295, 1967.Article
10.
Howard R, Wilson WS, Donn BJ:  Quantitative determination of choline acetylase, acetylcholine and acetylcholinesterase in the developing rabbit cornea . Invest Ophthalmol 12:418-425, 1973.
11.
Peterson RA, Lee K, Donn A:  Acetylcholinesterase in the rabbit cornea . Arch Ophthalmol 73:370-377, 1965.Article
12.
Laties A:  Localization in cornea and lens of topically applied irreversible cholinesterase inhibitors . Am J Ophthalmol 68:848-857, 1968.
13.
Gnädinger M:  Der histochemische nachweis von cholinesterase in kultivierten epithelzellen der kaninchen hornhaut . Albrecht von Graefes Arch Klin Ophthalmol 174:271-278, 1968.Article
14.
Medgyaszay A, Hegedüs J:  On the epithelialization of the cornea . Szemészet 104:66-69, 1967.
15.
Davanger M, Evensen A:  Role of the pericorneal papillary structure in renewal of corneal epithelium . Nature 229:560-561, 1971.Article
16.
Graf B, Pouliquen Y, Frouin MA, et al:  A morphologic study of the epithelium during the initial stages of healing of experimental wounds of the cornea . Arch Ophthalmol 31:895-910, 1971.
17.
Matsuda H, Smelser GK:  Epithelium and stroma in alkali-burned corneas . Arch Ophthalmol 89:396-401, 1973.Article
18.
Herrmann H, Hickman FH:  The adhesion of epithelium to stroma in the cornea . Bull Johns Hopkins Hosp 82:182-207, 1948.
19.
Herrmann H:  The effect of histamine and related substances on the cohesion of the corneal epithelium . Bull Johns Hopkins Hosp 82:208-212, 1948.
20.
Baier RE, Shafrin EG, Zisman WA: Mechanism assisting or impeding adhesion in biological systems. NRL Report 6691, May 3, 1968.
21.
Khodadoust AA:  Techniques for the preparation of sheets of pure corneal epithelium . Am J Ophthalmol 63:942-945, 1967.
22.
Khodadoust AA, Silverstein AM, Kenyon KR, et al:  Adhesion of regenerating corneal epithelium: The role of basement membrane . Am J Ophthalmol 65:339-348, 1968.
23.
Blümcke S, Rode J, Niedorf HR:  Formation of the basement membrane during regeneration of corneal epithelium . Z Zellforsch Mikrosk Anat 93:84-92, 1969.Article
24.
Harris TM, Sheppard B, Shanklin WM, et al:  A comparison of corneal epithelium regeneration in normal and buphthalmic rabbits . Invest Ophthalmol 9:122-130, 1970.
25.
Balazs EA (ed): The Chemistry and Molecular Biology of the Intercellular Matrix . London, Academic Press, 1970.
26.
Pullinger BD, Mann I:  Avascular healing in the cornea . J Pathol Bacteriol 55:151-158, 1943.Article
27.
Weimar VL, Haraguchi KH:  The lag phase of wound repair . Exp Eye Res 6:283-291, 1967.Article
28.
Graft B, Pouliquen Y, Frouin MA, et al:  The phenomena of reabsorption in the course of cicatrization of experimental wounds of the cornea . Exp Eye Res 13:24-32, 1972.Article
29.
Meyers RL, Pettit JH:  Chemotaxis of polymorphonuclear leukocytes in corneal inflammation: Tissue injury in herpes simplex virus infection . Invest Ophthalmol 13:187-197, 1974.
30.
Maumanee AE Kornblueth W:  Regeneration of corneal stromal cells: II. Review of literature and histologic study . Am J Ophthalmol 32:1052-1064, 1949.
31.
Weimar VL:  The transformation of corneal stromal cells to fibroblasts in corneal wound healing . Am J Ophthalmol 44:173-180, 1957.
32.
Weimar VL:  The sources of fibroblasts in corneal wound repair: A quantitative analysis . Arch Ophthalmol 60:93-109, 1958.Article
33.
Weimar VL:  Neutral red uptake by corneal epithelial cells and by injury activated corneal stromal cells: I. A comparison of the effects of various metabolic inhibitions and lysosome labeling and stabilizing agents . Exp Eye Res 11:57-69, 1971.Article
34.
Wolter JR:  Reactions of the cellular elements of the corneal stroma . Arch Ophthalmol 59:873-881, 1958.Article
35.
Kitano SL, Goldman JN:  Cytologic and histochemical changes in corneal wound repair . Arch Ophthalmol 76:345-354, 1966.Article
36.
Hanna C, O'Brien JE:  Thymidine-tritium labeling of cellular elements of corneal stroma . Arch Ophthalmol 66:362-365, 1961.Article
37.
Robb R, Kuwabara T:  Corneal wound healing: II. An autoradiographic study of the cellular components . Arch Ophthalmol 72:401-408, 1964.Article
38.
Baum JL:  Source of the fibroblast in central corneal wound healing . Arch Ophthalmol 85:473-477, 1971.Article
39.
Dohlman CH:  On the metabolism of the corneal graft . Acta Ophthalmol 35:303-310, 1957.Article
40.
Dunnington JH, Smelser GK:  Incorporation of S35 in healing wounds in normal and devitalized corneas . Arch Ophthalmol 60:116-129, 1958.Article
41.
Anseth A:  Glycosaminoglycans in corneal regeneration . Exp Eye Res 1:122-127, 1961.Article
42.
Dohlman CH, Praus R: The Mucopolysaccharides in Corneal Wound Healing in Biochemistry of the Eye . Basel, S Karger, 1968, pp 120-127.
43.
Cintron C, Schneider H, Kublin C:  Corneal scar formation . Exp Eye Res 17:251-259, 1973.Article
44.
Latessa AJ, Ross MH:  Electron microscope studies of non-penetrating corneal wounds in the early stages of healing . Exp Eye Res 3:298-303, 1964.Article
45.
Cogan DG:  A new method for studying endothelial regeneration . Ophthalmologica 118:441-443, 1949.Article
46.
Morton PL, Ormsby HL, Basu PK:  Healing of endothelium and Descemet's membrane of rabbit cornea . Am J Ophthalmol 46:62, 1958.
47.
Stocker FW:  The endothelium of the cornea and its clinical implications . Trans Am Ophthalmol Soc 51:669-786, 1953.
48.
Chi HH, Teng CC, Katzin HM:  Healing process in the mechanical denudation of the corneal endothelium . Am J Ophthalmol 49:693-703, 1960.
49.
Polack FM:  Four year retention of 3H thymidine by corneal endothelium . Arch Ophthalmol 75:659-660, 1966.Article
50.
Capella JA:  Regeneration of endothelium in diseased and injured corneas . Am J Ophthalmol 74:810-817, 1972.
51.
Brown SI, Kitano S:  Pathogenesis of the retrocorneal membrane . Arch Ophthalmol 75:518-525, 1966.Article
52.
Sherrard ES, Rycroft PU:  Retrocorneal membranes: I. Their origin and structure . Br J Ophthalmol 51:379-386, 1967.Article
53.
Sherrard ES, Rycroft PU:  Retrocorneal membranes: I. Factors influencing their growth . Br J Ophthalmol 51:387-394, 1967.Article
54.
Inomata H, Smelser GK, Polack FM:  Fine structure of regenerating endothelium and Descemet's membrane in normal and rejecting grafts . Am J Ophthalmol 70:48-64, 1970.
55.
Matsuda H, Smelser GK:  Endothelial cells in alkali burned corneas: Ultrastructural alterations . Arch Ophthalmol 89:402-409, 1973.Article
56.
Perlman M, Baum J:  Synthesis of a collagenous basal membrane by rabbit corneal endothelial cells in vitro . Arch Ophthalmol 92:238-239, 1974.Article
57.
Dunnington JH, Weimar VL:  Influence of the epithelium on the healing of corneal incisions . Am J Ophthalmol 45:89-95, 1958.
58.
Weimar VL, Haraguchi KH:  Growth stimulating effects of proteolytic enzymes on corneal tissues . Isr J Med Sci 8:1531-1536, 1972.
59.
Wine NA, Basu PK:  Studies on corneal wound healing: An in vitro approach . Am J Ophthalmol 58:253-258, 1964.
60.
Gasset AR, Dohlman CH:  The tensile strength of corneal wounds . Arch Ophthalmol 79:595-602, 1968.Article
61.
Dohlman CH, Gasset AR, Rose J:  The effect of the absence of corneal epithelium or endothelium on the stromal keratocytes . Invest Ophthalmol 7:520-534, 1968.
62.
Leuenberger PM, Gnädinger MC, Cabernard E:  Synthesis of collagen in corneal epithelium: I. Electron microscopic study on regenerated epithelium of the rabbit eye . Albrecht von Graefes Arch Klin Ophthalmol 87:171-182, 1973.Article
63.
Leuenberger PM, Gnädinger MC:  The role of epithelium in corneal wound healing . Arch Ophthalmol 32:33-42, 1972.
64.
Gnädinger MC:  Synthesis of hydroxyproline in corneal epithelium . Ophthalmol Res 3:198-206, 1972.Article
65.
Gnädinger MC, Refojo MF, Itoi M, et al:  The epithelium in corneal wound healing: An assay with tritiated proline . Ophthalmol Res 2:65-76, 1971.Article
66.
Green H, Goldberg B:  Synthesis of collagen by mammalian cell lines of fibroblastic and non-fibroblastic origin . Proc Natl Acad Sci USA 53:1360-1365, 1965.Article
67.
Hay ED, Revel JP:  Fine structure of the developing avian cornea  in: Developmental Biology . Basel, S Karger, 1969.
68.
Trelstadt RL:  Vacuoles in the embryonic chick: Corneal epithelium, an epithelium which produces collagen . J Cell Biol 48:648-694, 1971.
69.
Cameron JD, Flaxman BA, Yanoff M:  In vitro studies of corneal wound healing: Epithelial-endothelial interactions . Invest Ophthalmol 13:575-579, 1974.
70.
Matsuda H, Smelser GK:  Electron microscopy of corneal wound healing . Exp Eye Res 16:427-442, 1973.Article
71.
Dunnington JH, Regan EF:  The effect of sutures and of thrombin upon ocular wound healing . Am J Ophthalmol 35:167-177, 1952.
72.
Gliedman ML, Karlson KE:  Wound healing and wound strength of sutured limbal wounds . Am J Ophthalmol 39:859-866, 1955.
73.
Flaxel JT, Swan KC:  Limbal wound healing after cataract extraction: A histologic study . Arch Ophthalmol 81:653-659, 1969.Article
74.
Tarkkanen A, Esila R:  Corneal reactions to various suture materials . Acta Ophthalmol 44:613-619, 1966.Article
75.
Brumback GF, McPherson SD:  Reconstituted collagen sutures in corneal surgery . Am J Ophthalmol 64:222-227, 1967.
76.
Condon PI:  An experimental study of corneal wound healing with the use of more modern suture material . Trans Ophthalmol Soc UK 90:971-972, 1970.
77.
Basu PR, Hasany SM:  A histochemical study on corneal suture reactions . Can J Ophthalmol 6:328-341, 1971.
78.
Hill DW, Condon PI:  Measurement of the tensile strength of corneal tissues . Exp Eye Res 11:143-144, 1971.
79.
Condon PI, Hill DW:  Testing of experimental corneal wounds stitched with modern corneoscleral sutures: Experimental corneal wound healing: I. Microsurgical and tensiometric techniques and results . Ophthalmol Res 5:137-150, 1973.Article
80.
Chandler JW, Sugar J, Gasset AR:  Experimental corneal wound strength . Arch Ophthalmol 92:155-156, 1974.Article
81.
Partridge J, Rich A, Dunlap W, et al:  Ocular tissue fluids and nylon, virgin silk and collagen sutures . Arch Ophthalmol 90:271-273, 1973.Article
82.
Aronson SB, Moore TE Jr:  Suture reaction in the rabbit cornea . Arch Ophthalmol 82:531-536, 1969.Article
83.
Moore TE Jr, Aronson SB:  Suture reaction in the human cornea . Arch Ophthalmol 82:575-579, 1969.Article
84.
McMaster PRB, Aronson SB, Moore TE Jr:  Suture toxicity in the germfree guinea pig . Arch Ophthalmol 84:776-782, 1970.Article
85.
Harmes H, Mackensen G: Ocular Surgery Under the Microscope . Chicago, Year Book Medical Publishers Inc, 1967.
86.
McMaster PRB, Aronson SB, Moore TE Jr:  The role of indigenous bacteria in producing anterior ocular inflammation . Arch Ophthalmol 86:443-445, 1971.Article
87.
Brown SI, Tragakis MP:  Wound dehiscence with keratoplasty: Complication of the continuous-suture technique . Am J Ophthalmol 72:115-116, 1971.
88.
Friedman AH:  Wound rupture after keratoplasty . Am J Ophthalmol 75:117-120, 1973.
89.
Reed JW, Dohlman CH:  Corneal cysts: A report of eight cases . Arch Ophthalmol 86:648-652, 1971.Article
90.
Laibson PR:  Cornea and sclera . Arch Ophthalmol 85:738-761, 1971.Article
91.
Ashton N, Cook C:  Effect of cortisone on healing of corneal wounds . Br J Ophthalmol 35:708-717, 1951.Article
92.
Leopold IH, Purnell JE, Cannon EJ, et al:  Local and systemic cortisone in ocular disease . Am J Ophthalmol 34:361-371, 1951.
93.
Newell FW, Dixon JM:  Effect of subconjunctival cortisone upon the immediate union of experimental corneal grafts . Am J Ophthalmol 34:977-982, 1951.
94.
McDonald PR, Leopold IH, Vogel AW, et al:  Hydrocortisone (compound F) in ophthalmology . Arch Ophthalmol 49:400-412, 1953.Article
95.
Sigelman S, Dohlman CH, Friedenwald JS:  Mitotic and wound-healing activities in the rat corneal epithelium . Arch Ophthalmol 52:751-757, 1954.Article
96.
Palmerton ES:  The effect of local cortisone on wound healing in rabbit corneas . Am J Ophthalmol 40:344-353, 1955.
97.
Fink AI, Baras I:  Effects of steroids on tensile strength of corneal wounds . Am J Ophthalmol 42:759-764, 1958.
98.
Basu PK:  Effect of different steroids on healing of nonperforating corneal wounds in rabbits . Arch Ophthalmol 59:657-664, 1958.Article
99.
Beams R, Linabery L, Grayson M:  Effect of topical corticosteroids on corneal wound strength . Am J Ophthalmol 66:1131-1133, 1968.
100.
Aquavella JV, Gasset AR, Dohlman CH:  Corticosteroids in corneal wound healing . Am J Ophthalmol 58:621-626, 1964.
101.
Polack FM, Rosen PN:  Topical steroids and tritiated thymidine uptake . Arch Ophthalmol 77:400-404, 1967.Article
102.
Gasset AR, Lorenzetti DWC, Ellison EM, et al:  Quantitative corticosteroid effect on corneal wound healing . Arch Ophthalmol 81:589-591, 1969.Article
103.
Kara-José N, Lorenzetti DWC, McAuliffe R, et al:  Time response effects of corticosteroids on corneal wound healing . Can J Ophthalmol 7:48-51, 1972.
104.
Lorenzetti DWC, Kara-José N, McAuliffe R, et al:  Subconjunctival corticosteroids: Effects on corneal xenograft reactions and on corneal wound healing . Can J Ophthalmol 7:42-47, 1972.
105.
Sanchez J, Polack FM:  Effect of topical steroids on the healing of corneal endothelium . Invest Ophthalmol 13:17-22, 1974.
106.
McDonald TW:  Corneal wound healing . Invest Ophthalmol 9:703-709, 1970.
107.
Sugar J, Chandler JW:  Experimental corneal wound strength: Effect of topically applied corticosteroids . Arch Ophthalmol 92:248-249, 1974.Article
108.
Buxton JN, Apisson JG, Hoefle FB:  Corticosteroids in 100 keratoplasties . Am J Ophthalmol 67:47-51, 1969.
109.
Moore JE, Aronson SB:  The role of steroids in penetrating keratoplasty . Trans Ophthalmol Soc UK 89:379-396, 1969.
110.
Elliott JH, Leibowitz HM:  The influence of immunosuppressive agents upon corneal wound healing . Arch Ophthalmol 76:334-337, 1966.Article
111.
Laibson PR, Sery TW, Leopold IH:  Treatment of herpetic keratitis with 5-iodo-2′-deoxyuridine (IDU) . Arch Ophthalmol 70:52-58, 1963.Article
112.
Kaufman HE, Capella JA, Maloney ED, et al:  Corneal toxicity of cytosine arabinoside . Arch Ophthalmol 72:535-540, 1964.Article
113.
Polack FM, Rose J:  The effect of 5-iodo2′-deoxyuridine (IDU) in corneal healing . Arch Ophthalmol 71:520-527, 1964.Article
114.
Payrau P, Dohlman CH:  IDU in corneal wound healing . Am J Ophthalmol 57:999-1002, 1964.
115.
Schumacher H, Machemer R:  Influence of iodide uracil-desoxyriboside on regeneration of corneal stroma . Ophthalmologica 152:183-192, 1966.Article
116.
Hanna C:  Effect of IDU on DNA synthesis during corneal wound healing . Am J Ophthalmol 61:279-282, 1966.
117.
Langston RHS, Pavan-Langston D, Dohlman CH:  Antiviral medication and corneal wound healing . Arch Ophthalmol 92:509-513, 1974.Article
118.
Friedenwald JS, Buschke W:  Some factors concerned in the mitotic and wound healing activities of corneal epithelium . Trans Am Ophthalmol Soc 42:371-383, 1944.
119.
McDonald J, Wilder H:  The effect of beta radiation on corneal healing . Am J Ophthalmol 40:170-179, 1953.
120.
Michaelson IC, Schreiber H:  Influence of low voltage x-radiation on regression of established corneal vessels . Arch Opthalmol 55:48-51, 1956.Article
121.
Morrison DR, Kanai A, Gasset AR:  Beta radiation inhibition of corneal healing: I. Tensile strength and ultrastructural change . Invest Ophthalmol 10:826-839, 1971.
122.
Vrabec J:  Influence of beta radiation on the healing of corneal wounds . Cesk Oftalmol 29:327-330, 1973.
123.
Townes CD:  Unfavorable effects of alphachymotrypsin in cataract surgery . Arch Ophthalmol 64:108-113, 1960.Article
124.
Fink A, Bernstein HN, Birnhorst D:  Effect of L-chymotrypsin on corneal wound healing . Arch Ophthalmol 64:104-107, 1960.Article
125.
Bedrossian RH, Lalli RA:  Clinical application of new laboratory data on alpha-chymotrypsin . Arch Ophthalmol 67:616-621, 1962.Article
126.
Wind CA, Gasset AR:  The effect of L-chymotrypsin on intraocular pressure and corneal wound healing . Ann Ophthalmol 4:32-39, 1972.
127.
Oberberger J, Cejkova J:  Corneal damage following intracorneal injection of N-acetyl-L-cysteine . Albrecht von Graefes Arch Klin Ophthalmol 185:171-178, 1972.Article
128.
Lemp MA, Roddy MR:  The effect of acetylcysteine (Mucomyst) on reepithelialization of the cornea . Ann Ophthalmol 6:893-895, 1974.
129.
Behrendt T:  Experimental study of corneal lesions produced by topical anesthesia . Am J Ophthalmol 41:99-105, 1956.
130.
Epstein L, Paton D:  Keratitis from misuse of corneal anesthetics . N Engl J Med 279:396-399, 1963.Article
131.
Willis WE, Laibson PR:  Corneal complications of topical anesthetic abuse . Can J Ophthalmol 5:239-243, 1970.
132.
Berens C, DeGara PF, Loutfallah M:  Effect of sulfonamide ointment on healing of experimental wounds of rabbit cornea . Arch Ophthalmol 30:631-644, 1943.Article
133.
Smelser GK:  The influence of vehicles and form of penicillin and sulfonamides on mitosis and healing of corneal burns . Am J Ophthalmol 29:541-543, 1946.
134.
Leopold IH, Steele WH:  Influence of local application of sulfonamide compounds and their vehicles on regeneration of corneal epithelium . Arch Ophthalmol 33:463, 1945.Article
135.
Heerema JC, Friedenwald JS:  Retardation of wound healing in corneal epithelium by lanolin . Am J Ophthalmol 33:1421, 1950.
136.
Hanna C, Fraunfelder FT, Cable M, et al:  Effect of ophthalmic ointments on corneal wound healing . Am J Ophthalmol 76:193-200, 1973.
137.
Kolbert GS:  Oral diphenylhydantoin in corneal wound healing in the rabbit . Am J Ophthalmol 66:736-738, 1968.
138.
Cohen S:  Isolation of a mouse submacillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal . J Biol Chem 237:1555-1556, 1962.
139.
Frati L, Daniels S, Deloga A, et al:  Selective binding of the epidermal growth factor and its specific effects on epithelial cells of the cornea . Exp Eye Res 14:135-143, 1972.Article
140.
Savage CR Jr, Cohen S:  Proliferation of corneal epithelium induced by epidermal growth factor . Exp Eye Res 15:361-366, 1973.Article
141.
Ho PC, Davis WH, Elliott JH, et al:  Kinetics of corneal epithelial regeneration and epidermal growth factor . Invest Ophthalmol 13:804-809, 1974.
142.
MacManus JP, Whitfield JE, Rixon RH:  Control of normal cell proliferation , in Braun W, Lichtenstein LM, Parker CW (eds): Cyclic Amp, Cell Growth, and the Immune Response . New York, Springer-Verlag, 1974, pp 302-316.
×