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Article
January 1977

Intravitreal Amphotericin B Treatment of Candida Endophthalmitis

Author Affiliations

From the Retina and Pathology Services, Department of Ophthalmology, Northwestern University School of Medicine, Chicago.

Arch Ophthalmol. 1977;95(1):89-93. doi:10.1001/archopht.1977.04450010089008
Abstract

• A 43-year-old heroin addict with Candida albicans endophthalmitis was treated with a single 5-μg intravitreal injection of amphotericin B. The diagnosis was confirmed by smears and cultures of a vitreous aspiration. The patient's accidental death seven weeks after treatment enabled us to obtain histopathologic evidence that the infection had been cured and that the amphotericin B had had no toxic effect on the retina. Intravitreal amphotericin B should be considered an important mode of treatment of Candida endophthalmitis.

(Arch Ophthalmol 95:89-93, 1977)

References
1.
Michelson PE, Stark W, Reeser F, et al:  Endogenous Candida endophthalmitis: Report of 13 cases and 16 from the literature . Int Ophthalmol Clin 11:125-127, 1971.
2.
Griffin JR, Pettit TH, Fishman LS, et al:  Blood-borne Candida endophthalmitis: A clinical and pathologic study of 21 cases . Arch Ophthalmol 89:450-456, 1973.Article
3.
Fishman LS, Griffin JR, Sapico FL, et al:  Hematogenous Candida endophthalmitis: A complication of candidemia . N Engl J Med 286:675-681, 1972.Article
4.
Edwards JE Jr, Foos RY, Montgomerie JZ, et al:  A review of 76 cases of hematogenous Candida endophthalmitis . Medicine 53:47-75, 1974.Article
5.
Weinstein AJ, Johnson EH, Moellering RC Jr:  Candida endophthalmitis: A complication of candidemia . Arch Intern Med 132:740-753, 1973.Article
6.
Meyers BR, Lieberman TW, Perry AP:  Candida endophthalmitis complicating candidemia . Ann Intern Med 79:647-653, 1973.Article
7.
Freeman JB, Davis PL, MacLean LD:  Candida endophthalmitis associated with intravenous hyperalimentation . Arch Surg 108:237-240, 1974.Article
8.
Axelrod AJ, Peyman GA:  Intravitreal amphotericin B treatment of experimental fungal endophthalmitis . Am J Ophthalmol 76:584-588, 1973.
9.
Getnick RA, Rodrigues MM:  Endogenous fungal endophthalmitis in a drug addict . Am J Ophthalmol 77:680-683, 1974.
10.
Stone RD, Irvine AR, O'Connor GR:  Candida endophthalmitis: Report of an unusual case with isolation of the etiologic agent by vitreous biopsy . Ann Ophthalmol 7:757-762, 1975.
11.
Horne MJ, Ma MH, Taylor RF, et al:  Candida endophthalmitis . Med J Aust 1:170-172, 1975.
12.
Louria DB, Hensle T, Rose J:  The major medical complications of heroin addiction . Ann Intern Med 67:1-22, 1967.Article
13.
Dellon AL, Stark WJ, Chretien PB:  Spontaneous resolution of endogenous Candida endophthalmitis complicating intravenous hyperalimentation . Am J Ophthalmol 79:640-654, 1975.
14.
Robertson D, Riley F, Hermans PE:  Endogenous Candida oculomycosis: Report of two cases treated with flucytosine . Arch Ophthalmol 91:33-38, 1974.Article
15.
Jones BR:  Principles in the management of oculomycosis: Thirty-first Edward Jackson Memorial Lecture . Am J Ophthalmol 79:719-751, 1975.
16.
Walinder P-E, Kock E:  Endogenous fungus endophthalmitis . Acta Ophthalmol 49:263-272, 1971.Article
17.
Goodman LJ, Gilman A (eds): The Pharmacological Basis of Therapeutics . New York, McMillan Co, 1970, pp 1300-1302.
18.
Green WR, Bennett JE, Goos RD:  Ocular penetration of amphotericin B . Arch Ophthalmol 73:760-775, 1965.Article
19.
Axelrod AJ, Peyman GA, Apple DJ:  Toxicity of intravitreal injection of amphotericin B . Am J Ophthalmol 76:578-583, 1973.
20.
Souri EN, Green WR:  Intravitreal amphotericin B toxicity . Am J Ophthalmol 78:77-81, 1974.
21.
Toala P, Schroeder SA, Daly AK, et al:  Candida at Boston City Hospital: Clinical and Epidemiological characteristics and susceptibility to eight antimicrobial agents . Arch Intern Med 126:983-989, 1970.Article
22.
Clayton Y:  Antifungal drugs for oculomycosis: II. Sensitivity of certain ocular fungi to antifungal drugs . Trans Ophthalmol Soc UK 89:837-844, 1969.
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