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Article
February 1977

Soluble Artificial Tear Inserts

Author Affiliations

From the Departments of Ophthalmology (Dr Bloomfield) and the Rogosin Kidney Center (Drs Miyata, Stenzel, Rubin, and Ms Handle) the New York Hospital-Cornell Medical Center, and the Department of Ophthalmology, New York Medical College (Dr Dunn).

Arch Ophthalmol. 1977;95(2):247-250. doi:10.1001/archopht.1977.04450020048009
Abstract

• This article reports a new concept in the treatment of tear film abnormalities. Solubilization of an artificial tear insert provides a continuous flow of polymer into the tear film in place of intermittent drop therapy. The physiochemical properties of succinylated collagen were studied in vitro and compared favorably with presently available tear substitutes. The use of this polymer as a solid solubilizable insert was evaluated in normal patients. It was found to be comfortable, resulted in no blurring of vision, and prolonged the tear film breakup time.

(Arch Ophthalmol 95:247-250, 1977)

References
1.
Ehlers N:  The precorneal film . Acta Ophthalmol 81( (suppl) ):5-134, 1965.
2.
Benedetto OA, Shah DO, Kaufman HE:  The instilled fluid dynamics and surface chemistry of polymers in the preocular tear film . Invest Ophthalmol 14:887-902, 1975.
3.
Stenzel KH, Dunn MW, Rubin AL, et al:  Collagen gels: Design for a vitreous replacement . Science 164:1282-1283, 1969.Article
4.
White MJ, Kohno I, Rubin AL, et al:  Collagen film: Effect of cross-linking in physical and biological properties . Biomat Med Dev Art Org 1:703-715, 1973.
5.
Miyata T, Sohde T, Rubin AL, et al:  Effects of ultraviolet irradiation on native and telopeptide-poor collagen . Biochim Biophys Acta 229:672-680, 1971.Article
6.
McEwen WK:  Secretion of tears and blinking , in Davson H (ed): The Eye . New York, Academic Press Inc, 1962, vol 3, pp 271-305.
7.
Wolff E:  The muco-cutaneous junction of the lid-margin and the distribution of tear fluid . Trans Ophthalmol Soc UK 66:291-308, 1946.
8.
Lemp MA, Holly FJ, Iwata S, et al:  The precorneal tear film: Factors in spreading and maintaining a continuous tear film over the corneal surface . Arch Ophthalmol 83:89-94, 1970.Article
9.
Holly FJ, Lemp MA:  Wettability and wetting of corneal epithelium . Exp Eye Res 11:237-250, 1971.Article
10.
Lemp MA, Holly FJ:  Ophthalmic polymers as ocular wetting agents . Ann Ophthalmol 4:15-20, 1972.
11.
Chrai SS, Robinson JR:  Ocular evaluation of methylcellulose vehicle in albino rabbits . J Pharm Sci 63:1218-1223, 1974.Article
12.
Adamson AW: Physical Chemistry of Surfaces , ed 2. New York, Interscience Publishers Inc, 1967.
13.
Rubin AL, Riggio RR, Nachman RL, et al:  Collagen materials in dialysis and implantation . Trans Am Soc Artif Intern Organs 14:169-174, 1968.
14.
Rubin AL, Stenzel KH, Miyata T, et al:  Collagen as a vehicle for drug delivery: Preliminary report . J Clin Pharmacol 13:309-312, 1973.
15.
Lemp MA, Goldberg M, Roddy MR:  The effect of tear substitutes in tear film breakup time . Invest Ophthalmol 14:255-258, 1975.
16.
Lemp MA: Design and development of an artificial tear. Read before the American Academy of Ophthalmology and Otolaryngology, Dallas, Texas, 1975.
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