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February 1977

Aqueous Humor Ascorbate Concentration and Open-Angle Glaucoma

Author Affiliations

From the Departments of Ophthalmology (Drs Lee, Lam, and Lai) and Biochemistry (Dr Lam) Albany Medical College of Union University; and the Section of Ophthalmology, Surgical Service, Veterans Administration Hospital (Dr Lee) Albany, NY. Dr Lai is now with the Department of Ophthalmology, Howard University, Washington, DC.

Arch Ophthalmol. 1977;95(2):308-310. doi:10.1001/archopht.1977.04450020109018

• The mean value for aqueous concentration in 35 patients with open-angle glaucoma was 22.4 ± 12.9 mg/100 ml. The mean value for aqueous ascorbate in four patients with uncomplicated senile cataract was 11.55 ± 3.01 mg/100 ml. The results indicate that the majority of open-angle glaucomatous eyes do not involve a deficiency of ascorbate, and suggest that ascorbate has no therapeutic value in the management of primary open-angle glaucoma. The magnitude of aqueous ascorbate variation among glaucoma eyes is probably related to the factors that influence the patency of trabecular meshwork, not the metabolic activity of the ciliary processes.

(Arch Ophthalmol 95:308-310, 1977)

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