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Article
May 1977

Increased Cellular Responsiveness to Epinephrine in Primary Open-Angle Glaucoma

Author Affiliations

From the Department of Ophthalmology, Washington University School of Medicine, St Louis.

Arch Ophthalmol. 1977;95(5):855-856. doi:10.1001/archopht.1977.04450050133016
Abstract

• The concentration of I-epinephrine hydrochloride necessary to Inhibit lymphocyte transformation by 50% (I50 value) was determined in vitro for nine patients with primary open-angle glaucoma (POAG) and in seven controls. The lymphocytes of the patients with POAG were significantly (P <.05) more responsive. This result is consistent with the hypothesis that patients with POAG have an increased responsiveness to agents that elevate intracellular cyclic adenosine monophosphate levels.

(Arch Ophthalmol 95:855-856, 1977)

References
1.
Bigger JF, Palmberg PF, Becker B:  Increased cellular sensitivity to glucocorticoids in primary open-angle glaucoma . Invest Ophthalmol 11:832-837, 1972.
2.
Bigger JF, Palmberg PF, Zink HA:  In vitro corticosteroid response: Correlation with primary open-angle glaucoma and ocular corticosteroid sensitivity . Am J Ophthalmol 79:92-97, 1975.
3.
Zink HA, Palmberg PF, Bigger JF:  Increased sensitivity to theophylline associated with open-angle glaucoma . Invest Ophthalmol 12:603-607, 1973.
4.
Parker CW, Huber MG, Baumann ML:  Alterations in cyclic AMP metabolism in human bronchial asthma: III. Leukocyte and lymphocyte responses to steroids , J Clin Invest 52:1342-1348, 1973.Article
5.
Smith JW, Steiner AL, Newberry WM, et al:  Cyclic adenosine 3′,5′-monophosphate in human lymphocytes: Alterations after phytohemagglutinin stimulation . J Clin Invest 50:432-441, 1971.Article
6.
Palmberg PF, Rachlin D, Becker B:  Differential sensitivity at the cellular level in primary open-angle glaucoma: Prednisolone and ouabain . Invest Ophthalmol 15:403-405, 1976.
7.
Becker B:  Intraocular pressure response to topical corticosteroids , Invest Ophthalmol 4:198-205, 1965.
8.
Rosenberg SA, Levy R, Schechter B, et al:  A rapid microassay of cellular immunity in the guinea pig and mouse . Transplantation 13:541-545, 1972.Article
9.
Becker B, Montgomery SW, Kass MA, et al:  Increased ocular and systemic responsiveness to epinephrine in primary open-angle glaucoma . Arch Ophthalmol 95:789-791, 1977.Article
10.
Becker B, Shin DH:  Response to topical epinephrine: A practical prognostic test in patients with ocular hypertension . Arch Ophthalmol 94:2057-2058, 1976.Article
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