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September 1977

Chloramphenicol Penetration Into Eyes

Author Affiliations

Augusta, Ga
Washington, DC

Arch Ophthalmol. 1977;95(9):1650. doi:10.1001/archopht.1977.04450090172019

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To the Editor.—A recent article in the Archives compared various routes of chloramphenicol administration to the aqueous humor concentrations in rabbits.1 The highest values (20 to 40 mg/liter) were found with 1% and 2% ointments. A comparison was made between these observations and those in the literature.

One frequently cited report concerned our comparison of chloramphenicol penetration into eyes from different liquid vehicles.2 The technique that was used was a single, 0.05-ml drop administration followed by a wash of the external ocular surfaces with two 30-second rinses with 0.5 ml of distilled water. This procedure served to remove all surface drug, which afforded a comparison of the efficacy of the vehicle in surface drugretention capacity. However, George and Hanna, on at least three occasions, referred to the corneal bathing as a technique for drug administration rather than for drug removal.

The argument used by George and

George FJ, Hanna C:  Ocular penetration of chloramphenicol: Effects of route of administration . Arch Ophthalmol 95:879-882, 1977.Article
Green K, MacKeen DL:  Chloramphenicol retention on, and penetration into, the rabbit eye . Invest Ophthalmol 15:220-222, 1976.