[Skip to Content]
[Skip to Content Landing]
Article
December 1977

Neurotrophic Corneal Ulcers in Diabetes Mellitus

Author Affiliations

From the Cornea-External Disease Unit, Department of Ophthalmology, Medical College of Wisconsin, Milwaukee County Medical Complex.

Arch Ophthalmol. 1977;95(12):2193-2196. doi:10.1001/archopht.1977.04450120099012
Abstract

• Three patients with juvenile-onset insulin-dependent diabetes mellitus had neurotrophic keratitis and/or ulceration presumably related to their diabetes. We suggest that significant neurotrophic corneal disease can occur in diabetic patients. The neurotrophic keratitis and corneal ulcers responded to treatment.

(Arch Ophthalmol 95:2193-2196, 1977)

References
1.
Schwartz DE:  Corneal sensitivity in diabetics . Arch Ophthalmol 91:174-178, 1974.Article
2.
Cochet P, Bonnet R:  L'esthesiometrie Corneenne: Realisation et interet pratique . Bull Soc Ophtalmol Fr 61:541-550, 1961.
3.
Norn MS:  Dendritic keratitis: IV. Follow-up examination of corneal sensitivity . Acta Ophthalmol 48:383-395, 1970.Article
4.
Woltman HW, Wilder RM:  Diabetes mellitus: Pathologic changes in the spinal cord and peripheral nerves . Arch Intern Med 44:576-603, 1929.Article
5.
Fagerberg SE:  Studies on the pathogenesis of diabetic neuropathy: III. Diabetic neuropathy in relation to diabetic vessel complications . Acta Med Scand 157:401-406, 1957.Article
6.
Thomas PK, Lascelles RG:  The pathology of diabetic neuropathy . Q J Med 35:489-509, 1966.
7.
Chopra JS, Hurwitz LJ, Montgomery DAD:  The pathogenesis of sural nerve changes in diabetes mellitus . Brain 92:391-418, 1969.Article
8.
Winegrad AI:  Diabetic neuropathy . N Engl J Med 286:1261-1262, 1972.Article
9.
Greene DA, De Jesus PV, Winegrad AI:  Effects of insulin and dietary myoinositol on impaired peripheral motor nerve conduction velocity in acute streptozotocin diabetes . J Clin Invest 55:1326-1336, 1975.Article
10.
Quaranta CA:  Sulla frequenza di una particolare forma di alterazione corneale in diabetici . Ateneo Parmense 25:548-555, 1954.
11.
Ioli Spada G:  Ulteriore contributo allo Studio della cheratodistrofia epiteliale puntata diabetica . Boll Ocul 43:775-785, 1964.
12.
Scullica L, Proto F:  Rilievi clinici e statistici sulla sensibilitá corneale nei diabetici . Boll Ocul 44:944-954, 1965.
13.
De Haas EBH:  Desiccation of cornea and conjunctiva after sensory denervation . Arch Ophthalmol 67:79-92, 1962.Article
14.
Duke-Elder S: System of Ophthalmology . London, Henry Kimpton, 1965, vol 8, p 805.
15.
Sigelman S, Friedenwald JS:  Mitotic and wound-healing activities of the corneal epithelium: Effect of sensory denervation . Arch Ophthalmol 52:46-57, 1954.Article
16.
Awasthi P, Sarbhai KP, Maheshwari BB, et al:  Corneal sensations in diabetes mellitus . Trans XXII Int Congr Paris 1:402-409, 1974.
17.
Mandelcorn MS, Blankenship G, Machemer R:  Pars plana vitrectomy for the management of severe diabetic retinopathy . Am J Ophthalmol 81:561-570, 1976.
×