[Skip to Content]
[Skip to Content Landing]
Article
January 1978

Iris Metastasis From a Bronchial Carcinoid Tumor

Author Affiliations

From the Pathology Department and Oncology Unit, Retina Service, Wills Eye Hospital, Philadelphia. Dr Rodrigues is now with the Laboratory of Vision Research, NEI, Bethesda.

Arch Ophthalmol. 1978;96(1):77-83. doi:10.1001/archopht.1978.03910050041010
Abstract

• A 54-year-old man had a fleshy pink vascularized mass in the superonasal quadrant of the right iris. He had a history of an unchanging pulmonary nodule that was followed up for five years with routine chest roentgenograms. Fluorescein angiography demonstrated early filling of numerous fine blood vessels in the mass and diffuse late staining of the lesion. Results of a transcorneal radioactive phosphorus (32P) uptake test were positive. The clinical diagnosis was tapioca melanoma of the iris, with metastatic tumor as a second possibility. The tumor was excised by iridocyclectomy.

Light microscopy revealed nests of tumor cells with oval hyperchromatic nuclei. Fontana stains for melanin were negative as were argentaffin and argyrophil stains. Electron microscopy demonstrated light and dark tumor cells containing numerous membrane-bound electrondense neurosecretory granules. The diagnosis was iris metastasis from a probable bronchial carcinoid. The patient is alive and well three years after excision of the iris mass.

References
1.
Fu Y, McWilliams NB, Stratford TP, et al:  Bronchial carcinoid with choroidal metastasis in an adolescent . Cancer 33:707-715, 1974.Article
2.
Bell RM, Bullock JD, Albert DM:  Solitary choroidal metastasis from bronchial carcinoid . Br J Ophthalmol 59:155-163, 1975.Article
3.
Shields JA, Carmichael PL, Leonard BC, et al:  The radioactive phosphorus uptake test in the diagnosis of ocular tumors , in Croll MN, Brady LW, Carmichael PL, et al (eds): Nuclear Ophthalmology New York, John Wiley & Sons, Inc, 1976, pp 79-88.
4.
Reese AB, Mund ML, Owamoto T:  Tapioca melanoma of the iris: Part I. Clinical and light microscopy studies . Am J Ophthalmol 74:840-861, 1972.
5.
Ferry AP, Font RL:  Carcinoma metastatic to the eye and orbit: I. A clinicopathologic study of 227 cases . Arch Ophthalmol 92:276-286, 1974.Article
6.
Simpson AJ:  The carcinoid tumor, syndrome and spectrum . NC Med J 30:399-414, 1970.
7.
Weiss L, Ingram M:  Adenomatoid bronchial tumors: A consideration of the carcinoid tumors and the salivary tumors of the bronchial tree . Cancer 14:161-178, 1961.Article
8.
Rosai J, Rodriguez HA:  Application of electron microscopy to the differential diagnosis of tumors . Am J Clin Pathol 50:555-562, 1968.
9.
Hernandez FJ, Fernandez BB:  Mucussecreting colonic carcinoid tumors: Light and electron microscopic study of three cases . Dis Colon Rectum 17:387-396, 1974.Article
10.
Barter R, Pearse AGE:  Detection of 5-hydroxytryptamine in mammalian enterochromaffin cells . Nature 172:810-816, 1953.Article
11.
Gloor E, Campiche M, Bauman RP:  Mastocytes, autofluorescent and silver reducing elements in bronchial carcinoids . Virchows Arch [Pathol Anat] 357:19-28, 1972.Article
12.
Bensch KG, Gordon GB, Miller LR:  Electron microscopic and biochemical studies on the bronchial carcinoid tumor . Cancer 18:592-602, 1965.Article
13.
Patchefsky AS, Gordon G, Harrer WV, et al:  Carcinoid tumor of the pancreas: Ultrastructural observations of a lymph node metastasis and comparison with bronchial carcinoid . Cancer 33:1349-1354, 1974.Article
14.
Weichert RF, Rothe LM, Harkin JC:  Carcinoid-islet cell tumor of the duodenum and associated multiple carcinoid tumors of the ileum . Cancer 27:910-918, 1971.Article
15.
Soga J, Tazawa K, Ifo H:  Ultrastructural demonstration of specific secretory granules of Mastomys gastric carcinoids . Acta Med Biol 17:119-124, 1969.
16.
Ferry AP, Font RL:  Carcinoma metastatic to the eye and orbit: II. A clinicopathological study of 26 patients with carcinoma metastatic to the anterior segment of the eye . Arch Ophthalmol 93:472-482, 1975.Article
17.
Rosenbluth J, Laval J, Weil JV:  Metastasis of bronchial adenoma to the eye . Arch Ophthalmol 63:47-50, 1960.Article
18.
Fishman ML, Rosenthal S:  Optic nerve metastasis from a mediastinal carcinoid tumor . Br J Ophthalmol 60:583-588, 1976.Article
19.
Toker C, Fry WA, Head L, et al:  Bronchial adenoma (carcinoid type) . Cancer 19:1943-1948, 1966.Article
20.
Hajdu SI, Winawer SJ, Myers WPL:  Carcinoid tumors: A study of 204 cases . Am J Clin Pathol 61:521-528, 1974.
21.
O'Grady WP, McDivitt RW, Holman GW, et al:  Bronchial adenoma . Arch Surg 101:558-561, 1970.Article
22.
Deutsch AR, Duckworth JK:  Nonchromaffin paraganglioma of the orbit . Am J Ophthalmol 68:659-663, 1969.
23.
Litricin O:  Orbital nonchromaffin paraganglioma . Ann Oculist 203:585-592, 1970.
24.
Zawirska B, Drozdowska S:  Recurrent chemodectoma of the orbit . Ann Oculist 203:361-370, 1970.
×