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April 1979

Clostridium perfringens Corneal Ulcer

Author Affiliations

From the Cornea and External Disease Laboratory and Department of Ophthalmology, Northwestern University School of Medicine, Chicago. Dr Stern is currently with the Department of Ophthalmology, George Washington University School of Medicine, Washington, DC.

Arch Ophthalmol. 1979;97(4):661-663. doi:10.1001/archopht.1979.01020010317006

• A corneal ulcer caused by Clostridium perfringens developed in a 76-yearold woman with Sjögren's syndrome. Experimental C perfringens keratitis was induced in rabbits by the intrastromal injection of 107 organisms. In both our patient and the experimental animals, a bullous lesion overlay the affected area of the cornea. This may be a specific lesion in clostridial infections of the cornea. Clostridium perfringens should be regarded as an opportunistic corneal pathogen, and anaerobic cultures should be performed in all cases of suspected bacterial corneal ulcer.

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