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January 1980

Spontaneous Trends in Ocular Pressure in Untreated Ocular Hypertension

Author Affiliations

From the Department of Ophthalmology, New England Medical Center Hospital and Tufts University School of Medicine, Boston. Read in part before the annual meeting, Association for Research in Vision and Ophthalmology, Sarasota, Fla, May 1, 1978.

Arch Ophthalmol. 1980;98(1):105-111. doi:10.1001/archopht.1980.01020030107009

Sixty ocular hypertensive patients receiving no treatment with ocular pressures of 21 mm Hg or more were followed up for a median time of 42 months for changes in ocular pressure. Three significant patterns were observed—stability, downward trend, or an upward trend. The majority of patients showed relatively stable pressures over the course of time. Cyclic swings of pressure over one- or two-year periods were also observed. A group of 43 normal patients with ocular pressures less than 21 mm Hg showed no trends of pressure with time except for three who had a small increase. For some patients, ocular hypertension appears to be a specific entity that represents either stable pressures with time or an episode of increased pressure that eventually decreases. In patients whose pressures continue to increase, ocular hypertension may become true glaucoma. Evaluation of the course of ocular hypertension in relation to diagnosis and treatment is important, especially in terms of the efficacy of treatment.

Strömberg U:  Ocular hypertension . Acta Ophthalmol 69( (suppl) ):1-75, 1962.
Linnér E, Strömberg U:  Ocular hypertension: A five-year study of the total population in a Swedish town, Skovde , in Leydhecker W (ed): Glaucoma Tutzing Symposium . New York, S Karger, 1967, pp 187-214.
Graham PA:  The definition of pre-glaucoma: A prospective study . Trans Ophthalmol Soc UK 88:153-165, 1968.
Armaly MF:  Ocular pressure and visual fields: A ten-year follow-up study . Arch Ophthalmol 81:24-40, 1969.
Norskov K:  Routine tonometry in ophthalmic practice: II. Five-year follow-up . Acta Ophthalmol 48:873-895, 1970.Article
Schappert-Kimijser J:  A five-year follow-up of subjects with intraocular pressure of 22-30 mm Hg without anomalies of optic nerve and visual field typical for glaucoma at first investigation . Ophthalmologica 162:289-295, 1971.Article
Perkins ES:  The Bedford glaucoma survey: I. Long-term follow-up of borderline cases . Br J Ophthalmol 57:179-185, 1973.Article
Kitazawa Y, Horie T, Aoki S, et al:  Untreated ocular hypertension . Arch Ophthalmol 95:1180-1184, 1977.Article
Linnér E:  Ocular hypertension: I. The clinical course during ten years without therapy: Aqueous humor dynamics . Acta Ophthalmol 54:707-720, 1976.Article
Drance SM:  Visual field defects in glaucoma , in Symposium on Glaucoma: Transactions of the New Orleans Academy of Ophthalmology . St Louis, CV Mosby Co, 1975, pp 190-209.
Schwartz B:  Cupping and pallor of the optic disc . Arch Ophthalmol 89:272-277, 1973.Article
Schwartz B:  Correlation of pallor of optic disc with asymmetrical visual field loss in glaucoma , in XXII Concilium Ophthalmologicum, 1974 . Paris, Masson Publishers, 1976, vol 2, pp 632-638.
Siegel S: Nonparametric Statistics for the Behavioral Sciences . New York, McGraw-Hill Book Co, 1956.
Schwartz B:  Primary open angle glaucoma , in Duane TD (ed): Clinical Ophthalmology . New York, Harper & Row Publishers Inc, 1976, vol 3, pp 1-45.
Anderson DR:  The management of elevated intraocular pressure with normal optic disc and visual field: I. Therapeutic approach based on high risk factors . Surv Ophthalmol 21:479-489, 1977.Article
Linnér E:  A longitudinal study of ocular hypertension . Doc Ophthalmol 27:259-264, 1969.Article
Linnér E:  Diagnostic and therapeutic aspects of early chronic simple glaucoma . Israel J Med Sci 8:1394-1396, 1972.
Sorensen PN, Neilsen NV, Norskov K:  Ocular hypertension: A 15-year follow-up . Acta Ophthalmol 56:363-372, 1978.Article
Ederer F:  Serum cholesterol changes: Effects of diet and regression toward the mean . J Chronic Dis 25:277-289, 1972.Article
Levene RZ:  Annual review of glaucoma . Arch Ophthalmol 85:227-251, 1971.Article
Schwartz B, Levene RZ:  Plasma cortisol differences between normal and glaucomatous patients before and after dexamethasone suppression . Arch Ophthalmol 87:369-377, 1972.Article
Selye H: Stress in Health and Disease . Boston, Butterworth Publishers Inc, 1976.
Blumenthal M, Blumenthal R, Peritz E, et al:  Seasonal variation in intraocular pressure . Am J Ophthalmol 69:608-610, 1970.