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Article
March 1980

Keratitis due to Acanthamoeba castellaniA Clinicopathologic Case Report

Author Affiliations

From the Eye Pathology Laboratory, Wilmer Ophthalmological Institute, and Department of Pathology, Johns Hopkins Medical Institutions, Baltimore (Dr Green); Medical Research Service, Veterans Administration Medical Center, Gainesville, Fla (Drs Willaert and Stevens); and Departments of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville (Dr Stevens). Drs Key and Key are in private practice in Austin, Tex.

Arch Ophthalmol. 1980;98(3):475-479. doi:10.1001/archopht.1980.01020030471005
Abstract

• Trophozoites and cysts of amebas were found within the necrotic cornea of an enucleated eye. The organism was identified, by indirect immunofluorescent staining using specific antiserum, to be Acanthamoeba castellani. This case report illustrates the difficulty of clinical diagnosis and typical inefficacy of medical therapy shown in other reports of this rare keratitis.

References
1.
Carter RF:  Primary amoebic meningoencephalitis: An appraisal of present knowledge . Trans R Soc Trop Med Hyg 66:193-208, 1972.Article
2.
Nagington J, Watson PG, Playfair TJ, et al:  Amoebic infection of the eye . Lancet 2:1537-1540, 1974.Article
3.
Wang SS, Feldman HA:  Isolation of Hartmannella species from human throats . N Engl J Med 277:1174-1179, 1967.Article
4.
Ashton N, Stamm W:  Amoebic infection of the eye: A pathological report . Trans Ophthalmol Soc UK 95:214-220, 1975.
5.
Lund OE, Stefani FH, Dechant W:  Amoebic keratitis: A clinicopathologic case report . Br J Ophthalmol 62:373-375, 1978.Article
6.
Ma P, Juechter K: The sixth case of Acanthamoeba infection of the eye. Presented at the 79th Annual Meeting of the American Society of Microbiology, Los Angeles, May 4, 1979.
7.
Willaert E:  Etude immunotaxonomique des genres Naegleria et Acanthamoeba . Acta Zool Pathol Antverp 59:1-239, 1976.
8.
Stevens AR, Kilpatrick T, Willaert E, et al:  Serological analyses of cell surface antigens of Acanthamoeba species with plasma membrane antisera . J Protozool 24:316-324, 1977.Article
9.
Stevens AR, Willaert E:  A new method for purifying Acanthamoeba plasma membranes . Fed Proc 38:358, 1979.
10.
Willaert E, Stevens AR:  Immunoassays of Acanthamoeba castellani plasma membranes: Preliminary results . Pathol Biol 24:89-91, 1976.
11.
Visvesvara GS, Jones DB, Robinson NM:  Isolation, identification, and biological characterization of Acanthamoeba polyphaga from a human eye . Am J Trop Med Hyg 24:784-790, 1975.
12.
Jones DB, Visvesvara GS, Robinson NM:  Acanthamoeba polyphaga keratitis and Acanthamoeba uveitis associated with fatal meningoencephalitis . Trans Ophthalmol Soc UK 95:221-231, 1975.
13.
Watson PG:  Symposium on infection of the eye by Acanthamoeba: Amoebic infection of the eye . Trans Ophthalmol Soc UK 95:204-206, 1975.
14.
Jones BR, McGill JI, Steele ADM:  Recurrent suppurative kerato-uveitis with loss of eye due to infection by Acanthamoeba castellani . Trans Ophthalmol Soc UK 95:210-213, 1975.
15.
Robert VB, Rorke LB:  Primary amoebic encephalitis, probably from Acanthamoeba . Ann Intern Med 79:174-179, 1973.Article
16.
Jager BV, Stamm WP:  Brain abscess caused by free-living amoeba probably of the genus Hartmanella in a patient with Hodgkin's disease . Lancet 2:1343-1345, 1972.Article
17.
Willaert E, Stevens AR:  Indirect immunofluorescent identification of Acanthamoeba causing meningoencephalitis . Pathol Biol 24:545-547, 1976.
18.
Culbertson CG, Homes DH, Overton WM:  Hartmannella castellani (Acanthamoeba sp): Report on experimental chemotherapy . Am J Clin Pathol 43:361-364, 1965.
19.
Casemore DP:  Sensitivity of Hartmannella (Acanthamoeba) to 5-fluorocytosine, hydroxystilbamidine, and other substances .J Clin Pathol 23:649-652, 1970.Article
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