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September 1980

Intravitreal Expansion of Perfluorocarbon Bubbles

Author Affiliations

From the Department of Ophthalmology, The New York Hospital-Cornell Medical Center, New York.

Arch Ophthalmol. 1980;98(9):1646. doi:10.1001/archopht.1980.01020040498023

• The intraocular expansion of perfluoromethane (CF4), perfluoroethane (C2F6), and perfluoropropane (C3F8) was determined by a direct method for measuring intravitreal gas. A bubble of CF4 was found to expand 1.9 times the volume initially injected; C2F6 expanded 3.3 times; C3F8 expanded four times. The expansion characteristics of the experimental gases were compared with those of sulfur hexafluoride (SF6) and octofluorocyclobutane (C4F8), two gases already in clinical use.

Parver L, Lincoff H:  Mechanics of intraocular gas . Invest Ophthalmol 17:77-79, 1978.
Fineberg E, Machemer R, Sullivan P, et al:  Sulfurhexafluoride in owl monkey vitreous cavity . Am J Ophthalmol 79:67-74, 1975.