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Article
February 1981

H2-Receptors in the Human Ocular Surface

Author Affiliations

From the Department of Ophthalmology, Harvard Medical School, and the Department of Cornea Research, Eye Research Institute of Retina Foundation, Boston.

Arch Ophthalmol. 1981;99(2):302-304. doi:10.1001/archopht.1981.03930010304018
Abstract

• Ten normal human volunteers participated in a two-part study of H2-receptor activity in the ocular surface. Dimethylaminopropylisothiourea (trivial name, dimaprit dihydrochloride), a highly selective H2-receptor agonist, produced vasodilation without itch. Pretreatment with the H2-receptor antagonist, cimetidine, significantly blocked the vasodilatory effect of dimethylaminopropylisothiourea, whereas pretreatment with the H1-receptor antagonist, antazoline phosphate, did not. We conclude that H2-receptors are present in the human ocular surface.

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