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May 1981

Serologic Studies in Patients With Keratoconjunctivitis Sicca

Author Affiliations

From the Department of Ophthalmology (Dr S. L. Forstot) and the Division of Rheumatic Diseases, Department of Medicine (Drs J. Z. Forstot and Tan and Ms Peebles), University of Colorado Health Sciences Center, Denver.

Arch Ophthalmol. 1981;99(5):888-890. doi:10.1001/archopht.1981.03930010888021

• Thirty-two patients with keratoconjunctivitis sicca (KCS) were screened for the presence of antinuclear antibodies, rheumatoid factor, and autoantibodies associated with Sjögren's syndrome (designated SS-A and SS-B). None of these patients had or were found to have clinical evidence of a connective-tissue disease. The conditions of 19 (59%) patients were antinuclear-antibody-positive and 18 (56%) were rheumatoid-factor-positive. We found SS-A and/or SS-B autoantibodies in ten (31%) patients. There seems to be a high incidence of serologic abnormalities in patients with KCS, even when those patients with connective-tissue disease are excluded. Serologic testing seems to be a useful adjunct in the early diagnosis of primary Sjögren's syndrome. The presence of SS-A and SS-B autoantibodies correlated well with the clinical diagnosis of Sjögren's syndrome and seemed to identify the conditions of patients who may have a higher incidence of systemic complications with KCS.

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