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November 1981

Prolongation of Anti-inflammatory Effect of Prednisolone AcetateInfluence of Formulation in High-Viscosity Gel

Author Affiliations

From the Departments of Ophthalmology (Drs Kupferman and Leibowitz and Mr Ryan) and Pharmacology (Dr Kupferman), Boston University School of Medicine.

Arch Ophthalmol. 1981;99(11):2028-2029. doi:10.1001/archopht.1981.03930020904017

• Prednisolone acetate was formulated in a high-viscosity carboxypolymethylene gel at concentrations of 0.125% and 1.0%. The ability of these gel preparations to suppress inflammation in the cornea was assessed and compared with the anti-inflammatory capabilities of conventional commercially available prednisolone acetate ophthalmic suspensions. When administered hourly, the gel formulations produced no greater anti-inflammatory effect than the conventional suspensions. However, the gel formulations were equal in effect to the suspensions and maintained their effects considerably longer than did the suspensions. When applied at intervals up to and including four hours, there was no falloff in effect; the gel demonstrated a level of anti-inflammatory effectiveness that could not be distinguished from hourly administration of the suspension.

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