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Article
March 1982

Natural and Cloned Human Leukocyte Interferon in Herpesvirus Infections of Rabbit Eyes

Author Affiliations

From the Francis I. Proctor Foundation for Research in Ophthalmology and the Department of Ophthalmology, University of California, San Francisco (Drs Smolin, M. Friedlaender, and R. Friedlaender and Mr Okumoto); and Genentech, Inc, San Francisco (Dr Stebbing).

Arch Ophthalmol. 1982;100(3):481-483. doi:10.1001/archopht.1982.01030030483023
Abstract

• Human buffy-coat interferon and a leukocyte subtype (LeIF-A) obtained by gene cloning in Escherichia coli were equally effective in ameliorating the course of herpetic keratitis in rabbits when applied topically at a daily dose of 0.5 x 106 units per eye for six days commencing one day before infection. When given intramuscularly at the same dose, there was no alteration in the course of the disease. Topical treatments with LeIF-A were equally effective in suppressing epithelial damage seven days after infection, regardless of whether treatment commenced one day before infection or two days after infection. However, treatment from the day before infection also caused a significant decrease in epithelial defect two days after infection.

References
1.
Goeddel DV, Yelverton E, Ullrich A, et al:  Human leukocyte interferon produced by E. coli is biologically active . Nature 1980;287:411-416.Article
2.
Nagata S, Mantei N, Weissmann C:  The structure of one of the eight or more distinct chromosomal genes for human interferon-α . Nature 1980;287:401-408.Article
3.
Goeddel DV, Leung DW, Dull TJ, et al: The structure of eight distinct cloned human leukocyte interferon cDNAs. Nature, to be published.
4.
Sundmacher R, Cantell K, Huag P, et al:  Role of debridement and interferon in the treatment of dendritic keratitis . Albrecht Von Graefes Arch Klin Exp Ophthalmol 1978;207:77-82.Article
5.
Jones BR, Coster DJ, Falcon MG, et al:  Topical therapy of ulcerative herpetic keratitis with human interferon . Lancet 1976;2:128-129.Article
6.
Sundmacher R, Cantell K, Neumann-Haefelin D:  Combination therapy of dendritic keratitis with trifluorothymidine and interferon . Lancet 1978;2:687.Article
7.
Pazin GJ, Armstrong JA, Lam MT, et al:  Prevention of reactivated herpes simplex infection by human leukocyte interferon after operation on the trigeminal root . N Engl J Med 1979;301:225-230.Article
8.
Herberman RB, Djeu JV, Ortaldo JR, et al:  Role of interferon in augmentation of natural and antibody-dependent cell-mediated cytotoxicity . Cancer Treat Rep 1978;62:1893-1896.
9.
Eremin O, Wilson AB, Coombs RRA, et al:  Antibody-dependent cellular cytotoxicity in the rat, rabbit and guinea pig . Cell Immunol 1979;47:332-346.Article
10.
Desmyter J, Rawls WC, Melnick JL:  Sensitivity of rabbit cells to primate interferons . Ann NY Acad Sci 1970;173:492-504.Article
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