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April 1982

Amiodarone KeratopathyCorrelation to Dosage and Duration

Author Affiliations

From the Division of Ophthalmology, Department of Surgery, Case Western Reserve University Hospitals, Cleveland (Dr Kaplan), and Cleveland Metropolitan General Hospital (Dr Cappaert).

Arch Ophthalmol. 1982;100(4):601-602. doi:10.1001/archopht.1982.01030030603011

• Amiodarone hydrochloride, a benzofurane derivative used for the treatment of cardiac arrhythmias, is known to cause a verticillate epithelial keratopathy, which has been classified into three stages. Patients receiving low dosages of 100 to 200 mg of amiodarone daily retain clear corneas or show stage 1 changes only, regardless of duration of treatment or total amount of substance ingested. Patients receiving higher dosages of 400 to 1,400 mg/day show stage 2 and 3 changes, depending on duration of treatment. This keratopathy progresses, even with reduced dosage; however, complete regression occurs once administration of medication is discontinued.

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