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October 1982

Iris Nodules in von Recklinghausen's NeurofibromatosisElectron Microscopic Confirmation of Their Melanocytic Origin

Author Affiliations

From the Departments of Ophthalmology, Long Island Jewish-Hillside Medical Center and Health Sciences Center, Stony Brook, NY (Dr Perry), and the Cullen Eye Institute, Baylor College of Medicine, Houston (Dr Font).

Arch Ophthalmol. 1982;100(10):1635-1640. doi:10.1001/archopht.1982.01030040613012

• A 75-year-old man had generalized neurofibromatosis (NFT) with bilateral iris nodules and a mature cataract with elevated intraocular pressure in his left eye. At the time of intracapsular cataract extraction, a sector iridectomy was performed. Electron microscopic studies of the iris nodules within the iridectomy specimen unequivocally established that the spindle-shaped cells within the nodules were of melanocytic origin. We believe that the iris nodules in NFT represent melanocytic hamartomas.

Font RL, Ferry AP:  The phakomatoses . Int Ophthalmol Clin 1972;12:1-50.
Waardenberg PJ:  Genetics and Ophthalmology , vol 2, in Neuro-Ophthalmology , Assen, the Netherlands, van Gorcum, 1963, pp 1340-1356.
Lisch K:  Ueber Beteiligung der Augen, insbesondere das Vorkommen von Irisknötchen bei der Neurofibromatose (Recklinghausen) . Z Augenheilkd 1937;92:137-143.
Lewis RA, Riccardi VM:  Von Recklinghausen neurofibromatosis: Incidence of iris hamartomata . Ophthalmology 1981;88:348-354.Article
Unger K:  Neurofibromatosis iridis (Recklinghausen disease) . Arch Ophthalmol 1947; 38:654.Article
Wolter JR:  Solitary neurofibroma of the iris: Report of a case . J Pediat Ophthalmol Strabismus 1969;6:84-87.
Goldstein I, Wexler D:  Melanosis uveae and melanoma of the iris in neurofibromatosis (Recklinghausen) . Arch Ophthalmol 1930;3:288-296.Article
Wiznia RA, Freedman JK, Mancini AD, et al:  Malignant melanoma of the choroid in neurofibromatosis . Am J Ophthalmol 1978;86:684-687.
Wolter JR, Butler RG:  Pigment spots of the iris and ectropion uveae with glaucoma in neurofibromatosis . Am J Ophthalmol 1963;56:%964-973.
Nordmann J, Brini A:  Von Recklinghausen's disease and melanoma of the uvea . Br J Ophthalmol 1970;54:641-648.Article
Reese AB, Mund ML, Iwamoto T:  Tapioca melanoma of the iris: I. Clinical and light microscopy studies . Am J Ophthalmol 1972;74:840-850.
Feinman NL, Yakovac WC:  Neurofibromatosis in childhood . J Pediatr 1970;76:339-346.Article
Iwamoto T, Reese A, Mund M:  Tapioca melanoma of the iris: II. Electron microscopy of the melanoma cells compared with normal iris melanocytes . Am J Ophthalmol 1972;74:851-861.
Iwamoto T, Jones IS, Howard GM:  Ultrastructural comparison of spindle A, spindle B, and epithelioid type cells in uveal malignant melanoma . Invest Ophthalmol Vis Sci 1972; 11:873-889.